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<p>Pemphigoid gestationis (PG) is a rare autoimmune blistering condition that develops during pregnancy. It is characterized by pruritic erythematous papules and plaques that progress to tight bullae, generally on the periumbilical abdomen in the second or third trimester. The condition is caused by IgG autoantibodies that target BP180 (collagen XVII), which are activated by the abnormal expression of MHC class II antigens in placental tissues. Although PG has been linked to autoimmune thyroid problems, its full comorbidity spectrum has yet to be investigated. To address this, a large-scale retrospective case-control study using the TriNetX worldwide federated health research network examined 35,355 patients with PG and matched controls. The study found statistically significant associations between PG and pruritus, asthma, alopecia areata, autoimmune thyroiditis, thyrotoxicosis with diffuse goiter, urticaria, seborrheic dermatitis, and psoriasis, but not lichen planus, vitamin B12 deficiency, allergic rhinitis, ulcerative colitis, atopic dermatitis, vitiligo, systemic sclerosis, or acute disseminated encephalitis and encephalomyelitis. These data imply that PG patients have a distinct autoimmune and inflammatory comorbidity profile, emphasizing the need for focused screening and more longitudinal research.</p>

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Evaluating the risk of autoimmune and pruritic conditions in pemphigoid gestationis: a propensity score-matched analysis

  • 期刊论文

  • 发表日期：

    2026年7月11日

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  • Kritin K. Verma,
  • Ryan S. Koch,
  • Brenna Bunch,
  • Dora Ryan Goldstein,
  • Robert P. Kauffman,
  • Daniel P. Friedmann,
  • Alexis Borden,
  • Michelle B. Tarbox

摘要

Pemphigoid gestationis (PG) is a rare autoimmune blistering condition that develops during pregnancy. It is characterized by pruritic erythematous papules and plaques that progress to tight bullae, generally on the periumbilical abdomen in the second or third trimester. The condition is caused by IgG autoantibodies that target BP180 (collagen XVII), which are activated by the abnormal expression of MHC class II antigens in placental tissues. Although PG has been linked to autoimmune thyroid problems, its full comorbidity spectrum has yet to be investigated. To address this, a large-scale retrospective case-control study using the TriNetX worldwide federated health research network examined 35,355 patients with PG and matched controls. The study found statistically significant associations between PG and pruritus, asthma, alopecia areata, autoimmune thyroiditis, thyrotoxicosis with diffuse goiter, urticaria, seborrheic dermatitis, and psoriasis, but not lichen planus, vitamin B12 deficiency, allergic rhinitis, ulcerative colitis, atopic dermatitis, vitiligo, systemic sclerosis, or acute disseminated encephalitis and encephalomyelitis. These data imply that PG patients have a distinct autoimmune and inflammatory comorbidity profile, emphasizing the need for focused screening and more longitudinal research.