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<p>With increasing age, a decrease in volume occurs in the temporal fossa, which requires the use of safe and highly effective methods to improve this condition; Hyaluronic Acid fillers are non-invasive methods used for facial contouring. The present study aimed to determine the efficacy and safety of hyaluronic acid, a dermal filler, for temporal fossa augmentation.A search for relevant articles was conducted without time limits until June 2025 in the international databases PubMed, EMBASE, and Web of Science. Relevant keywords were used for the search; the present study aims to answer the question of whether HA dermal filler (Population (P)) is highly safety and effectiveness (Outcome (O)) in temporal fossa augmentation (Population (P)). Data analyses were conducted using the meta-analysis packages in STATA/MP.v17 (College Station, Texas, USA). Effect size with 95% confidence intervals were calculated using a fixed-effects model and inverse variance method.Present meta-analysis included a total of three RCT studies and three prospective studies encompassing 430 patients that received HA filler to improve temporal fossa. The ATHS responder rate was 80% (ES: 80% 95% CI 72 to 89%; I<sup>2</sup> = 0%). GAIS responder rate after HA filler treatment for temporal fossa augmentation was 84% (ES: 84% 95% CI 80 to 88%; I<sup>2</sup> = 10.39%). For ISRs, 55% of participants (ES: 55% 95% CI 48 to 63%) reported at least 1 ISR after initial treatment (I<sup>2</sup> = 0%). Post-injection pain was the most common ISR reported, observed in 43% of patients (ES: 43% 95% CI 38 to 48%). The test of sub-group meta-analysis showed there was a statistically significant difference between the reported ISRs (<i>p</i> &lt; 0.001).The available evidence suggests that HA fillers may be an effective and generally well-tolerated option for temporal fossa augmentation, with improvements observed in both short- and long-term follow-up periods. However, these findings should be interpreted with caution due to the limited number of available studies, the inclusion of both randomized and non-randomized designs, and the relatively small sample sizes.</p>

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Temporal fossa augmentation with hyaluronic acid dermal filler: a systematic review and meta-analysis

  • 期刊论文

  • 发表日期：

    2026年7月17日

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  • Amir Hashemloo,
  • Maryam Milanifard

摘要

With increasing age, a decrease in volume occurs in the temporal fossa, which requires the use of safe and highly effective methods to improve this condition; Hyaluronic Acid fillers are non-invasive methods used for facial contouring. The present study aimed to determine the efficacy and safety of hyaluronic acid, a dermal filler, for temporal fossa augmentation.A search for relevant articles was conducted without time limits until June 2025 in the international databases PubMed, EMBASE, and Web of Science. Relevant keywords were used for the search; the present study aims to answer the question of whether HA dermal filler (Population (P)) is highly safety and effectiveness (Outcome (O)) in temporal fossa augmentation (Population (P)). Data analyses were conducted using the meta-analysis packages in STATA/MP.v17 (College Station, Texas, USA). Effect size with 95% confidence intervals were calculated using a fixed-effects model and inverse variance method.Present meta-analysis included a total of three RCT studies and three prospective studies encompassing 430 patients that received HA filler to improve temporal fossa. The ATHS responder rate was 80% (ES: 80% 95% CI 72 to 89%; I2 = 0%). GAIS responder rate after HA filler treatment for temporal fossa augmentation was 84% (ES: 84% 95% CI 80 to 88%; I2 = 10.39%). For ISRs, 55% of participants (ES: 55% 95% CI 48 to 63%) reported at least 1 ISR after initial treatment (I2 = 0%). Post-injection pain was the most common ISR reported, observed in 43% of patients (ES: 43% 95% CI 38 to 48%). The test of sub-group meta-analysis showed there was a statistically significant difference between the reported ISRs (p < 0.001).The available evidence suggests that HA fillers may be an effective and generally well-tolerated option for temporal fossa augmentation, with improvements observed in both short- and long-term follow-up periods. However, these findings should be interpreted with caution due to the limited number of available studies, the inclusion of both randomized and non-randomized designs, and the relatively small sample sizes.