Scholarlink

<p>Paraneoplastic dermatoses are skin diseases associated with underlying internal malignancy. They may follow the course of cancer, making them clinically relevant as an external clue for both patients and physicians. This systematic review evaluated the diagnostic value and clinical implications of paraneoplastic dermatoses in early cancer detection. This systematic review was conducted using PRISMA guidelines. A comprehensive search was performed in PubMed, Cochrane, Web of Science, and VHL databases on August 13, 2025, with study screening, eligibility assessment, and data extraction conducted between August 2025 and December 2025. Original studies, including observational studies, case reports, and case series, evaluating paraneoplastic dermatoses as biomarkers or predictors for internal malignancy, were included. Non-English and non-original studies were excluded. Reporting quality assessment was conducted using STROBE for observational studies and CARE guidelines for case reports and case series. Findings were synthesized qualitatively. The search strategy yielded 262 articles, but 34 articles met the inclusion criteria, characterizing a total of 212 patients. Included studies consisted primarily of case reports and case series, along with a limited number of retrospective and prospective studies. Many paraneoplastic dermatoses were identified, including acanthosis nigricans, Leser-Trélat sign, and dermatomyositis, which were associated with various cancers. Their temporal relationship with malignancy, pathophysiologic mechanisms, and clinical implications were described. Paraneoplastic dermatoses are valuable clinical tools that may serve as important clinical indicators of underlying malignancy. They can encourage earlier cancer evaluation, direct surveillance for relapses, and trigger further investigation. However, because much of the current evidence on paraneoplastic dermatoses relies on case reports and case series, limiting definitive conclusions. Further evaluation of their predictive value using larger prospective studies is required to understand their clinical relevance.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Paraneoplastic dermatoses as biomarkers for internal malignancies: a systematic review

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月3日

查看全文
  • Mehraeel E. Saleh,
  • Emma N. Dang,
  • Ahmed Adham R. Elsayed,
  • Marc D. Basson

摘要

Paraneoplastic dermatoses are skin diseases associated with underlying internal malignancy. They may follow the course of cancer, making them clinically relevant as an external clue for both patients and physicians. This systematic review evaluated the diagnostic value and clinical implications of paraneoplastic dermatoses in early cancer detection. This systematic review was conducted using PRISMA guidelines. A comprehensive search was performed in PubMed, Cochrane, Web of Science, and VHL databases on August 13, 2025, with study screening, eligibility assessment, and data extraction conducted between August 2025 and December 2025. Original studies, including observational studies, case reports, and case series, evaluating paraneoplastic dermatoses as biomarkers or predictors for internal malignancy, were included. Non-English and non-original studies were excluded. Reporting quality assessment was conducted using STROBE for observational studies and CARE guidelines for case reports and case series. Findings were synthesized qualitatively. The search strategy yielded 262 articles, but 34 articles met the inclusion criteria, characterizing a total of 212 patients. Included studies consisted primarily of case reports and case series, along with a limited number of retrospective and prospective studies. Many paraneoplastic dermatoses were identified, including acanthosis nigricans, Leser-Trélat sign, and dermatomyositis, which were associated with various cancers. Their temporal relationship with malignancy, pathophysiologic mechanisms, and clinical implications were described. Paraneoplastic dermatoses are valuable clinical tools that may serve as important clinical indicators of underlying malignancy. They can encourage earlier cancer evaluation, direct surveillance for relapses, and trigger further investigation. However, because much of the current evidence on paraneoplastic dermatoses relies on case reports and case series, limiting definitive conclusions. Further evaluation of their predictive value using larger prospective studies is required to understand their clinical relevance.