<p>Seborrheic dermatitis is a common chronic inflammatory skin disorder, yet its impact on quality of life is poorly characterized. We conducted a cross-sectional study with validated patient-reported outcome measures and semi-structured qualitative interviews to describe the lived experiences of adults with seborrheic dermatitis, including disease burden, treatment experiences, perceived triggers, and effects on quality of life and self-esteem. Adults (≥ 18 years) with a clinical diagnosis of seborrheic dermatitis receiving care in outpatient dermatology clinic at a large academic medical center in the United States were contacted by email. Interviews took place between August 2024 and March 2025 and analyzed using thematic content analysis. Participants completed the Scalpdex, Dermatology Life Quality Index (DLQI), and State Self-Esteem Scale. Twenty participants completed interviews (mean age 38.3 <i>±</i> 11.8 years; 53% female; 55% White, 40% Black), and 18 completed all questionnaires. Participants with scalp and facial involvement (<i>n</i> = 11) reported greater disease burden than those with scalp involvement alone, with higher mean (standard deviation) Scalpdex scores (58.7 [5.6] vs. 54.8 [5.5]) and DLQI (5.0 [4.3] vs. 1.3 [1.0]). Qualitative themes included embarrassment, reduced self-esteem, social withdrawal, and frustration with complex regimens and fluctuating disease control. Stress and lifestyle factors were frequently cited as perceived triggers. Black participants reported additional challenges integrating recommended washing and topical regimens with hair care practices and protective styles. Overall, adults with seborrheic dermatitis reported physical and mental burdens affecting daily life. These issues highlight the need for further research to better define disease impact and inform strategies to optimize patient-centered care.</p>