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<p>Anxiety is bidirectionally related to psoriasis, and relieving it is beneficial for both physical and psychological patients with psoriasis. In this study, we aimed to explore the prevalence of generalized anxiety and risk factors in patients with psoriasis that are potentially modifiable in Shanghai, China. During 2022 and 2024, we recruited patients with psoriasis from the Shanghai Skin Disease Hospital. We applied the generalized anxiety disorder scale (GAD-7) for anxiety disorder evaluation, and patients with a GAD-7 score ≥ 5 were identified as having anxiety disorders. A structured questionnaire, onsite physical examination, and a disease severity assessment were used for data collection. Data were analyzed using SAS 9.4, and a P value less than 0.05 was considered as statistical significance. In total, 1116 psoriasis patients were recruited, who were predominantly male (74.4%) with an average age of 47.1 years (standard deviation [SD] = 16.8). The mean score of GAD-7 was 5.8, and 59.6% of the patients had anxiety, while the prevalence of psoriasis patients with mild, moderate, and severe anxiety was respectively 47.5%, 10.2%, and 1.9%. Logistic regression analysis indicated patients with lower monthly income had higher anxiety prevalence, the odds ratio (OR) was 1.75 (95% CI 1.21–2.54) for 668–1333 USD, compared with those with over 1333 USD per month. Patients with a PASI score ≥ 10 had a higher prevalence of anxiety (OR = 1.35, 95 CI 1.05–1.73) than those with a PASI score &lt; 10; patients with a short disease duration had a higher anxiety prevalence (OR, 1.60 (95% CI 1.20–2.15) and 1.28 (95% CI 0.91–1.79) for &lt; 5 and 5–10 years, respectively. Patients without alcohol drink had a higher prevalence of anxiety (OR = 1.47, 95% CI 1.07–2.01). The prevalence of anxiety was high among psoriasis patients, especially for those with lower monthly income, high PASI scores, short disease duration, and without alcohol drinking habits. We recommend that dermatologists should be sensitive to these vulnerable subgroups and implement psychological interventions as adjuncts to psoriasis therapy.</p>

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Anxiety disorder prevalence and associated risk factors among patients with psoriasis: findings from a psoriasis cohort in Shanghai, China

  • 期刊论文

  • 发表日期：

    2026年6月18日

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  • Yuning Ding,
  • Dongmei Liu,
  • Quanruo Xu,
  • Zhen Duan,
  • Lingzi Shenfan,
  • Rui Zhang,
  • Xiangjin Gao,
  • Ruiping Wang

摘要

Anxiety is bidirectionally related to psoriasis, and relieving it is beneficial for both physical and psychological patients with psoriasis. In this study, we aimed to explore the prevalence of generalized anxiety and risk factors in patients with psoriasis that are potentially modifiable in Shanghai, China. During 2022 and 2024, we recruited patients with psoriasis from the Shanghai Skin Disease Hospital. We applied the generalized anxiety disorder scale (GAD-7) for anxiety disorder evaluation, and patients with a GAD-7 score ≥ 5 were identified as having anxiety disorders. A structured questionnaire, onsite physical examination, and a disease severity assessment were used for data collection. Data were analyzed using SAS 9.4, and a P value less than 0.05 was considered as statistical significance. In total, 1116 psoriasis patients were recruited, who were predominantly male (74.4%) with an average age of 47.1 years (standard deviation [SD] = 16.8). The mean score of GAD-7 was 5.8, and 59.6% of the patients had anxiety, while the prevalence of psoriasis patients with mild, moderate, and severe anxiety was respectively 47.5%, 10.2%, and 1.9%. Logistic regression analysis indicated patients with lower monthly income had higher anxiety prevalence, the odds ratio (OR) was 1.75 (95% CI 1.21–2.54) for 668–1333 USD, compared with those with over 1333 USD per month. Patients with a PASI score ≥ 10 had a higher prevalence of anxiety (OR = 1.35, 95 CI 1.05–1.73) than those with a PASI score < 10; patients with a short disease duration had a higher anxiety prevalence (OR, 1.60 (95% CI 1.20–2.15) and 1.28 (95% CI 0.91–1.79) for < 5 and 5–10 years, respectively. Patients without alcohol drink had a higher prevalence of anxiety (OR = 1.47, 95% CI 1.07–2.01). The prevalence of anxiety was high among psoriasis patients, especially for those with lower monthly income, high PASI scores, short disease duration, and without alcohol drinking habits. We recommend that dermatologists should be sensitive to these vulnerable subgroups and implement psychological interventions as adjuncts to psoriasis therapy.