Scholarlink

<p>Atopic dermatitis (AD) is a chronic inflammatory skin disorder that significantly impacts patients’ quality of life. Although emerging research highlights the role of microbial dysbiosis in AD, the precise mechanisms of interaction between the skin and gut microbiota in the context of AD remain poorly understood. This systematic review synthesizes findings from studies comparing the microbiomes of AD patients and healthy controls, with a focus on the advances in amplicon sequencing and metagenomic sequencing. Seventeen studies, encompassing 665 AD patients and 768 healthy controls, were included in the review. These studies demonstrated significant microbial diversity shifts in AD patients, including a reduction in microbial diversity and shifts in specific microbial populations. These microbial alterations are thought to contribute to immune dysregulation, which plays a key role in AD pathogenesis. However, despite the growing body of evidence, the complex interactions between skin and gut microbiota and their exact contributions to AD remain insufficiently explored. This review highlights the need for further research into the gut-skin microbiome axis in AD, with an emphasis on how these microbial changes could lead to novel therapeutic strategies. Potential interventions such as probiotics, prebiotics, or other microbiome-based therapies could offer new treatment options for AD patients. The findings underscore the importance of continued investigation into microbial pathogenesis in AD to better inform future therapeutic approaches.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The gut and skin microbiome in atopic dermatitis: a systematic review of microbial dysbiosis and the gut-skin axis

  • 期刊论文

  • 发表日期：

    2026年5月29日

查看全文
  • Pengfei Yu,
  • Xin Lin,
  • Li Lin,
  • Kaiyuan Xue,
  • Jingwen Yang,
  • Xiaohan Dong,
  • Hongtao Xu,
  • Yukun Ren,
  • Rui Yuan,
  • Yuepeng An,
  • Suqing Yang,
  • Chen Xu

摘要

Atopic dermatitis (AD) is a chronic inflammatory skin disorder that significantly impacts patients’ quality of life. Although emerging research highlights the role of microbial dysbiosis in AD, the precise mechanisms of interaction between the skin and gut microbiota in the context of AD remain poorly understood. This systematic review synthesizes findings from studies comparing the microbiomes of AD patients and healthy controls, with a focus on the advances in amplicon sequencing and metagenomic sequencing. Seventeen studies, encompassing 665 AD patients and 768 healthy controls, were included in the review. These studies demonstrated significant microbial diversity shifts in AD patients, including a reduction in microbial diversity and shifts in specific microbial populations. These microbial alterations are thought to contribute to immune dysregulation, which plays a key role in AD pathogenesis. However, despite the growing body of evidence, the complex interactions between skin and gut microbiota and their exact contributions to AD remain insufficiently explored. This review highlights the need for further research into the gut-skin microbiome axis in AD, with an emphasis on how these microbial changes could lead to novel therapeutic strategies. Potential interventions such as probiotics, prebiotics, or other microbiome-based therapies could offer new treatment options for AD patients. The findings underscore the importance of continued investigation into microbial pathogenesis in AD to better inform future therapeutic approaches.