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<p>The etiology of premature greying hair (PGH) is still undiscovered, making it a challenge for dermatologists. PGH may be influenced by oxidative stress, which damages melanocytes and impairs melanin production. This study investigates the association between serum levels of vitamin C, vitamin E, and total antioxidant capacity with PGH. This case-control study was conducted among the population of Mashhad. Thirty patients diagnosed with PGH (age of onset &lt; 20 years; 8 males and 22 females) and 30 age- and sex-matched controls (7 males and 23 females) were enrolled. Serum levels of vitamin C, vitamin E, and total antioxidant capacity were evaluated in both groups. Family history of PGH was significantly higher in the case group compared to control group (<i>P</i> &lt; 0.001). Serum levels of vitamin C were not significantly different between case and control groups (0.77 ± 0.39&#xa0;mg/dL vs. 0.86 ± 0.47&#xa0;mg/dL; <i>P</i> = 0.592). Similarly, vitamin E serum levels were not significantly different in both groups (13.44 ± 3.34&#xa0;mg/L vs. 13.58 ± 4.02&#xa0;mg/L; <i>P</i> = 0.884). In addition, total antioxidant capacity was also not significantly different between both two groups (0.77 ± 0.35 vs. 0.63 ± 0.26; <i>P</i> = 0.075). While vitamin C, vitamin E, and total antioxidant capacity serum levels did not differ significantly between patients with PGH and controls, a strong association with family history was observed. These findings suggest a genetic predisposition and highlight the need for further research into oxidative mechanisms in PGH.</p>

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Serum levels of vitamin C, vitamin E, and total antioxidant capacity in premature graying hair

  • 期刊论文

  • 发表日期：

    2026年5月26日

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  • Mohammadali Kerachian,
  • Fatemeh Fazelifard,
  • Amirali Reihani,
  • Michael Saeed,
  • Reyhaneh Fazeli,
  • Amirhossein Derakhshan Doghaei,
  • Nazanin Rasti,
  • Zahra Hadavi,
  • Seyyed Pouria Hosseini,
  • Seyedeh Shabnam Mazloumi Kiapey,
  • Bita Kiafar,
  • Ahmad Reza Taheri,
  • Seyed Isaac Hashemy

摘要

The etiology of premature greying hair (PGH) is still undiscovered, making it a challenge for dermatologists. PGH may be influenced by oxidative stress, which damages melanocytes and impairs melanin production. This study investigates the association between serum levels of vitamin C, vitamin E, and total antioxidant capacity with PGH. This case-control study was conducted among the population of Mashhad. Thirty patients diagnosed with PGH (age of onset < 20 years; 8 males and 22 females) and 30 age- and sex-matched controls (7 males and 23 females) were enrolled. Serum levels of vitamin C, vitamin E, and total antioxidant capacity were evaluated in both groups. Family history of PGH was significantly higher in the case group compared to control group (P < 0.001). Serum levels of vitamin C were not significantly different between case and control groups (0.77 ± 0.39 mg/dL vs. 0.86 ± 0.47 mg/dL; P = 0.592). Similarly, vitamin E serum levels were not significantly different in both groups (13.44 ± 3.34 mg/L vs. 13.58 ± 4.02 mg/L; P = 0.884). In addition, total antioxidant capacity was also not significantly different between both two groups (0.77 ± 0.35 vs. 0.63 ± 0.26; P = 0.075). While vitamin C, vitamin E, and total antioxidant capacity serum levels did not differ significantly between patients with PGH and controls, a strong association with family history was observed. These findings suggest a genetic predisposition and highlight the need for further research into oxidative mechanisms in PGH.