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<p>Vasodilators have proven efficacy in hair growth induction. Amlodipine, a potent vasodilator with antioxidant, anti-inflammatory, and anti-apoptotic properties, may aid in promoting hair follicle proliferation. This study aimed to evaluate the hair growth–promoting effects of topical amlodipine cream in a mouse alopecia model.40 male Swiss albino mice were randomized into 4 groups (<i>n</i> = 10): untreated control, vehicle (1:1 Vaseline and lanolin), 5% amlodipine cream, and 2% minoxidil solution. Treatments were applied for 21 days, and hair growth underwent visual, histological, and immunohistochemical assessment. Topical amlodipine accelerated anagen induction, prolonged the anagen phase, and upregulated VEGF expression compared with controls. The hair growth-promoting effects of amlodipine were comparable to those of minoxidil. This preclinical study demonstrates the therapeutic potential of topical amlodipine in promoting hair growth, supporting its possible future role in alopecia treatment pending further preclinical and clinical validation.</p>

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Amlodipine topical cream: an effective hair growth promoter for an alopecia mouse model via VEGF-mediated angiogenesis and vasodilation

  • 期刊论文

  • 发表日期：

    2026年3月18日

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  • Zainab Azal Mahdi,
  • Ahmed Rahmah Abu-Raghif,
  • Samer Salim Shahooth,
  • Kholod Abbas Ali,
  • Raid Mohamed Al abood,
  • Ammar S. Al Khafaji,
  • Hayder Ridha-Salman

摘要

Vasodilators have proven efficacy in hair growth induction. Amlodipine, a potent vasodilator with antioxidant, anti-inflammatory, and anti-apoptotic properties, may aid in promoting hair follicle proliferation. This study aimed to evaluate the hair growth–promoting effects of topical amlodipine cream in a mouse alopecia model.40 male Swiss albino mice were randomized into 4 groups (n = 10): untreated control, vehicle (1:1 Vaseline and lanolin), 5% amlodipine cream, and 2% minoxidil solution. Treatments were applied for 21 days, and hair growth underwent visual, histological, and immunohistochemical assessment. Topical amlodipine accelerated anagen induction, prolonged the anagen phase, and upregulated VEGF expression compared with controls. The hair growth-promoting effects of amlodipine were comparable to those of minoxidil. This preclinical study demonstrates the therapeutic potential of topical amlodipine in promoting hair growth, supporting its possible future role in alopecia treatment pending further preclinical and clinical validation.