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<p>Turner syndrome (TS) exhibit small height, a webbed neck, cubitus valgus, and gonadal dysgenesis. In addition to these traits, individuals with TS may have challenging dermatological issues. However, there is currently a lack of data in the literature regarding skin-related conditions and their prevalence in TS. The Embase, PubMed, and Cochrane databases were systematically searched for studies up to May 2024 that assessed the skin manifestations in patients with TS. A random-effects model calculated the proportion with a 95% confidence interval. The most prevalent skin condition identified was xerosis, occurring in 65.02% of cases. It was followed by acquired melanocytic nevi at 55.62%, lymphedema at 31.35%, onychodystrophy at 20.02%, and keloids at 11.86%. Less common conditions included acne at 10.17%, atopic dermatitis at 7.70%, halo nevi at 6.98%, hirsutism at 5.34%, alopecia areata at 4.00%, vitiligo at 3.61%, psoriasis at 3.50%, melanoma at 1.33%, and lichen sclerosus at 0.56%. This meta-analysis identified xerosis, acquired melanocytic nevi, lymphedema, onychodystrophy, and keloids as the most frequent dermatological findings in TS. While common features in TS are not unique to this population, identifying them is crucial for improving management and enhancing the quality of life for these patients.</p>

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Cutaneous manifestations in Turner syndrome: a systematic review and meta-analysis

  • 期刊论文

  • 发表日期：

    2026年3月18日

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  • Beatriz Ximenes Mendes,
  • Lilia Maria Lima de Oliveira,
  • Deivyd Vieira Silva Cavalcante,
  • Lyria de Oliveira Rosa,
  • Michele Kreuz,
  • Sarah Soares Amorim,
  • Fabiana Castro Porto Silva Lopes

摘要

Turner syndrome (TS) exhibit small height, a webbed neck, cubitus valgus, and gonadal dysgenesis. In addition to these traits, individuals with TS may have challenging dermatological issues. However, there is currently a lack of data in the literature regarding skin-related conditions and their prevalence in TS. The Embase, PubMed, and Cochrane databases were systematically searched for studies up to May 2024 that assessed the skin manifestations in patients with TS. A random-effects model calculated the proportion with a 95% confidence interval. The most prevalent skin condition identified was xerosis, occurring in 65.02% of cases. It was followed by acquired melanocytic nevi at 55.62%, lymphedema at 31.35%, onychodystrophy at 20.02%, and keloids at 11.86%. Less common conditions included acne at 10.17%, atopic dermatitis at 7.70%, halo nevi at 6.98%, hirsutism at 5.34%, alopecia areata at 4.00%, vitiligo at 3.61%, psoriasis at 3.50%, melanoma at 1.33%, and lichen sclerosus at 0.56%. This meta-analysis identified xerosis, acquired melanocytic nevi, lymphedema, onychodystrophy, and keloids as the most frequent dermatological findings in TS. While common features in TS are not unique to this population, identifying them is crucial for improving management and enhancing the quality of life for these patients.