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Background <p>Demodex mites have been identified in many skin disorders. It is unclear whether <i>Demodex</i> mites can directly cause skin disorders, as they can be a commensal parasite when their number remains below five per cm².</p> Objectives <p>finding the correlation between demodicosis and different facial skin diseases.</p> Patients and methods <p>This case–control study included 121 patients with facial skin lesions and 121 controls. clinical examination, dermoscopic evaluation, and microscopic examination of skin by standardized superficial skin biopsy were performed for all participants.</p> Results <p>By dermoscopy Demodex mites were detected in 73.6% of all examined patients compared to only 1.7% in the control group. Standardized superficial skin biopsy revealed high Demodex density in 66.9% of the patient group, compared to only 1.7% in the control group. The most common skin disease in the patient group was pityriasis folliculorum (69.4%), followed by acne (14.0%), seborrheic dermatitis (9.9%), rosacea (5.8%), and discoid lupus erythematosus (0.8%).</p> Conclusion <p>Demodex colonization is associated with some facial dermatoses, and its treatment could potentially enhance overall therapeutic outcomes. Dermoscopy and standardized superficial skin biopsy are valuable, noninvasive tools for the diagnosis of demodicosis.</p>

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Demodicosis in facial dermatoses: clinical, dermoscopic, and standardized superficial skin biopsy evaluation a case control study

  • 期刊论文

  • 发表日期：

    2026年2月7日

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  • Zeinab Mohammed Faik,
  • Rafiaa Rashad Hussain,
  • Eman Mohammed Mahmoud,
  • Sara Ahmed Galal

摘要

Background

Demodex mites have been identified in many skin disorders. It is unclear whether Demodex mites can directly cause skin disorders, as they can be a commensal parasite when their number remains below five per cm².

Objectives

finding the correlation between demodicosis and different facial skin diseases.

Patients and methods

This case–control study included 121 patients with facial skin lesions and 121 controls. clinical examination, dermoscopic evaluation, and microscopic examination of skin by standardized superficial skin biopsy were performed for all participants.

Results

By dermoscopy Demodex mites were detected in 73.6% of all examined patients compared to only 1.7% in the control group. Standardized superficial skin biopsy revealed high Demodex density in 66.9% of the patient group, compared to only 1.7% in the control group. The most common skin disease in the patient group was pityriasis folliculorum (69.4%), followed by acne (14.0%), seborrheic dermatitis (9.9%), rosacea (5.8%), and discoid lupus erythematosus (0.8%).

Conclusion

Demodex colonization is associated with some facial dermatoses, and its treatment could potentially enhance overall therapeutic outcomes. Dermoscopy and standardized superficial skin biopsy are valuable, noninvasive tools for the diagnosis of demodicosis.