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Background <p>Acanthosis nigricans (AN) is a cutaneous disorder characterized by brown to black, poorly circumscribed, velvety hyperpigmentation that is sometimes associated with hyperkeratotic plaques. Treatment options for AN have not been well studied; however, smaller powered clinical trials and case reports exist in the literature.</p> Objective <p>to compare clinical efficacy, tolerability and safety of intralesional vitamin D3 cholecalciferol solution versus GA 70% peeling in the treatment of obesity associated AN of the neck.</p> Patients and methods <p>This prospective randomized comparative study was carried on 20 patients with AN. All patients had split-neck therapy, with one side receiving 70% glycolic acid peeling and the other side receiving intralesional vitamin D3 injections over the course of six sessions every two weeks. Follow up for three months after the final session was done. Acanthosis nigricans area and severity index (ANASI) score before, after treatment and after follow up was used for objective evaluation beside the dermoscopic evaluation.</p> Results <p>There was a statistically significant reduction of ANASI score in both vitamin D3 injection and glycolic acid 70% peeling sides after treatment and after the follow up compared with ANASI score before treatment with p-value = 0.000 in each. A statistically significant superior reduction of ANASI score in the glycolic 70% peeling side after treatment (p-value = 0.039) and after the follow up (p-value = 0.042) compared with vitamin D3 injection side. Also, a statistically significant improvement of dermoscopic signs with both vitamin D3 injection and glycolic acid 70% peeling after treatment with a p-value = 0.000 in each. No statistically significant difference was found between vitamin D3 injection side and glycolic acid 70% peeling side after treatment regarding dermoscopic signs. The vitamin D3 injection side had a slightly higher incidence of side effects, including hyperpigmentation (5%), erythema (10%), and injection site pain (15%). The GA side only reported erythema (15%) as a side effect.</p> Conclusion <p>Both Intralesional vitamin D3 and glycolic acid 70% peeling are effective, tolerable and safe for acanthosis nigricans treatment. GA peeling shows higher clinical efficacy irrespective of age, duration, BMI and severity.</p>

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Intralesional vitamin D3 versus glycolic acid 70% peeling in pseudo-acanthosis nigricans treatment: a randomized comparative study

  • 期刊论文

  • 发表日期：

    2026年1月7日

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  • Nayera Hassan Moftah,
  • Mervat Hamdino,
  • Afnan Refaat Mansour,
  • Alzahraa Mohammed Gamal-edeen

摘要

Background

Acanthosis nigricans (AN) is a cutaneous disorder characterized by brown to black, poorly circumscribed, velvety hyperpigmentation that is sometimes associated with hyperkeratotic plaques. Treatment options for AN have not been well studied; however, smaller powered clinical trials and case reports exist in the literature.

Objective

to compare clinical efficacy, tolerability and safety of intralesional vitamin D3 cholecalciferol solution versus GA 70% peeling in the treatment of obesity associated AN of the neck.

Patients and methods

This prospective randomized comparative study was carried on 20 patients with AN. All patients had split-neck therapy, with one side receiving 70% glycolic acid peeling and the other side receiving intralesional vitamin D3 injections over the course of six sessions every two weeks. Follow up for three months after the final session was done. Acanthosis nigricans area and severity index (ANASI) score before, after treatment and after follow up was used for objective evaluation beside the dermoscopic evaluation.

Results

There was a statistically significant reduction of ANASI score in both vitamin D3 injection and glycolic acid 70% peeling sides after treatment and after the follow up compared with ANASI score before treatment with p-value = 0.000 in each. A statistically significant superior reduction of ANASI score in the glycolic 70% peeling side after treatment (p-value = 0.039) and after the follow up (p-value = 0.042) compared with vitamin D3 injection side. Also, a statistically significant improvement of dermoscopic signs with both vitamin D3 injection and glycolic acid 70% peeling after treatment with a p-value = 0.000 in each. No statistically significant difference was found between vitamin D3 injection side and glycolic acid 70% peeling side after treatment regarding dermoscopic signs. The vitamin D3 injection side had a slightly higher incidence of side effects, including hyperpigmentation (5%), erythema (10%), and injection site pain (15%). The GA side only reported erythema (15%) as a side effect.

Conclusion

Both Intralesional vitamin D3 and glycolic acid 70% peeling are effective, tolerable and safe for acanthosis nigricans treatment. GA peeling shows higher clinical efficacy irrespective of age, duration, BMI and severity.