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Background <p>Given the relationship between vitamin A consumption and skeletal changes, there have been concerns about whether isotretinoin may be associated with decreased bone mineral density.</p> Objective <p>The objective of this study was to evaluate changes in bone mineral density among those treated with isotretinoin.</p> Methods <p>PubMed and Web of Science were searched for relevant studies. Two investigators independently screened abstracts and performed full-text review. Data were synthesized using random-effects models.</p> Results <p>Eight studies were identified, including 729 individuals. For studies including a comparison to a control cohort, there was a mean difference in bone mineral density of − 0.037&#xa0;g/cm<sup>2</sup> (95% CI -0.074 to 0.000) at the spine, − 0.048&#xa0;g/cm<sup>2</sup> (95% CI − 0.103 to 0.007) at the total hip, and − 0.075&#xa0;g/cm<sup>2</sup> (95% CI -0.138 to -0.011) at the femoral neck. For studies with a pre-post design, there was a percent change of 1.367% (95% CI 0.532 to 2.201) at the spine, -0.137% (95% CI -1.609 to 1.335) at total hip, and − 0.903% (95% CI -2.417 to 0.610) at the femoral neck.</p> Conclusions <p>There do not appear to be negative effects of isotretinoin on bone mineral density, though there may be some slight effects at the femoral neck. Longer-term studies are needed to further evaluate potential effects on bone mineral density.</p>

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The effect of isotretinoin on bone mineral density: a systematic review and meta-analysis

  • 期刊论文

  • 发表日期：

    2025年12月19日

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  • Sherry Ershadi,
  • Samantha Gregoire,
  • Katherine Sanchez,
  • Ursula Biba,
  • Sharon H. Chou,
  • Arash Mostaghimi,
  • John S. Barbieri

摘要

Background

Given the relationship between vitamin A consumption and skeletal changes, there have been concerns about whether isotretinoin may be associated with decreased bone mineral density.

Objective

The objective of this study was to evaluate changes in bone mineral density among those treated with isotretinoin.

Methods

PubMed and Web of Science were searched for relevant studies. Two investigators independently screened abstracts and performed full-text review. Data were synthesized using random-effects models.

Results

Eight studies were identified, including 729 individuals. For studies including a comparison to a control cohort, there was a mean difference in bone mineral density of − 0.037 g/cm2 (95% CI -0.074 to 0.000) at the spine, − 0.048 g/cm2 (95% CI − 0.103 to 0.007) at the total hip, and − 0.075 g/cm2 (95% CI -0.138 to -0.011) at the femoral neck. For studies with a pre-post design, there was a percent change of 1.367% (95% CI 0.532 to 2.201) at the spine, -0.137% (95% CI -1.609 to 1.335) at total hip, and − 0.903% (95% CI -2.417 to 0.610) at the femoral neck.

Conclusions

There do not appear to be negative effects of isotretinoin on bone mineral density, though there may be some slight effects at the femoral neck. Longer-term studies are needed to further evaluate potential effects on bone mineral density.