<p>Skin injury refers to the disruption of skin integrity, resulting in the loss of normal tissue, which can occur due to wounds, diseases, or surgeries. The repair of skin injuries is a highly regulated process involving cell migration, proliferation, collagen matrix deposition, and tissue remodeling, all of which are intricately linked to inflammation and angiogenesis. Angiogenesis—the formation of new blood vessels—plays a pivotal role in this process by ensuring the delivery of oxygen and nutrients that are essential for healing. Key angiogenic factors, such as vascular endothelial growth factor, fibroblast growth factor, and platelet-derived growth factor, are crucial in regulating vascular formation. Recent advances have shed light on the complex interactions between angiogenesis and inflammatory responses, emphasizing their critical roles in wound healing, scar formation, and tissue remodeling. However, effectively regulating angiogenesis in clinical settings remains challenging due to the complexity of its underlying mechanisms. This review offers a comprehensive analysis of angiogenesis in skin injury repair, focusing on its regulatory mechanisms, functional roles during different stages of healing, and therapeutic strategies aimed at optimizing vascularization for enhanced clinical outcomes. By advancing our understanding of angiogenesis, we seek to contribute to the development of innovative treatments for skin injuries.</p>