<p>Patient anxiety and satisfaction are crucial factors in Mohs Micrographic Surgery (MMS). Anxiety often arises from concerns about the diagnosis, pain, complications, cosmetic outcomes, and operating room environment. Additionally, Mohs patients may also question physician competency and experience. Treatment specific factors including drapes and anesthesia are also associated with anxiety, which can negatively impact patient experience. Our scoping review aimed to assess the effectiveness of preoperative and perioperative interventions in reducing anxiety and improving patient experience during MMS. Our findings showed that video education improved patient experience but did not decrease anxiety. 3D models showed inconsistent results. Pharmacologic interventions, such as anxiolytics and acetaminophen, were somewhat effective in reducing anxiety but had no significant impact on pain. Acetaminophen + carbohydrate loading was effective in reducing anxiety. Non-pharmacologic strategies, including music therapy, weighted blankets, and virtual reality consistently reduced anxiety. Our study is limited by small sample sizes and studies lacking blinding. Evidence on interventions for reducing anxiety in MMS is limited, but several hold promise. Further research with larger sample sizes is needed to comprehensively evaluate these therapies along with evaluating a combination of therapies.</p>