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<p>Morphea (localized scleroderma) is a chronic, autoimmune disease of connective tissue that has been known for many years. However, the etiology of the disease is still not fully understood. The study was conducted on a group of 88 people, including 59 patients with morphea and 29 people qualified for the control group. We attempted to assess gene expression and plasma concentration IL-1β, IL-18 and IL-33. In the group of patients with morphea, a lower expression of <i>IL1 beta</i> and <i>IL18</i> genes was observed in PBMC compared to the control group, and no significant differences in plasma concentrations of IL-1β, IL-18 and IL-33 were found in the group of patients with morphea compared to the control group.</p>

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The role of selected cytokines from the interleukin 1 family in the pathophysiology of morphea

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月16日

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  • Paulina Cieplewicz-Guźla,
  • Michał J. Kowalczyk,
  • Aleksandra Dańczak-Pazdrowska,
  • Ryszard Żaba,
  • Joanna Wegner,
  • Adriana Polańska

摘要

Morphea (localized scleroderma) is a chronic, autoimmune disease of connective tissue that has been known for many years. However, the etiology of the disease is still not fully understood. The study was conducted on a group of 88 people, including 59 patients with morphea and 29 people qualified for the control group. We attempted to assess gene expression and plasma concentration IL-1β, IL-18 and IL-33. In the group of patients with morphea, a lower expression of IL1 beta and IL18 genes was observed in PBMC compared to the control group, and no significant differences in plasma concentrations of IL-1β, IL-18 and IL-33 were found in the group of patients with morphea compared to the control group.