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<p>Developing polyphenol-loaded hydrogels can not only address the poor antibacterial and anti-inflammatory performance of single hydrogels, but also overcome the disadvantages of low bioavailability and poor stability of bioactive polyphenols. A novel cyclodextrin supramolecular drug-loaded hydrogel was constructed in this study, using carboxymethyl-β-cyclodextrin and polyethylene glycol-functionalized chitosan as raw materials, β-glycerophosphate sodium as the crosslinking agent and tannic acid (TA) as the drug model. The construction was realized through the synergistic effects of chemical crosslinking, electrostatic interaction, host-guest interaction, hydrogen bonding interaction, as well as supramolecular assembly driven by multiple interaction. Influence of various factors on the gelation time was investigated, and the properties of swelling, adsorption, rheology, antioxidant, drug-controlled release, antibacterial, and biocompatibility were systematically evaluated. Under optimal conditions, the gelation time of the cyclodextrin supramolecular hydrogel was 18&#xa0;s, and the adsorption capacity for TA reached 315.2&#xa0;mg/g, achieving controlled, sustained and long-lasting release. When the concentration of the drug-loaded gel reached 25&#xa0;µg/mL, the DPPH radical scavenging rate was 91.9%, indicating excellent antioxidant properties. The antibacterial rates against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> were 98.4% and 98.9%, respectively, demonstrating good antibacterial performance. The cytotoxicity was grade 0, indicating good biocompatibility. Based on the in vitro evaluation results, this cyclodextrin-based supramolecular hydrogel shows promising potential as a wound dressing for the treatment of difficult-to-heal wounds, providing a feasible candidate for the development of novel medical dressing in the medical field.</p>

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Polyphenol-loaded supramolecular hydrogels based on cyclodextrin as wound dressings

  • 期刊论文

  • 发表日期：

    2026年5月19日

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  • Fei Liang,
  • Yancheng Liu,
  • Bowen Duan,
  • Yihan Feng,
  • Na Xie

摘要

Developing polyphenol-loaded hydrogels can not only address the poor antibacterial and anti-inflammatory performance of single hydrogels, but also overcome the disadvantages of low bioavailability and poor stability of bioactive polyphenols. A novel cyclodextrin supramolecular drug-loaded hydrogel was constructed in this study, using carboxymethyl-β-cyclodextrin and polyethylene glycol-functionalized chitosan as raw materials, β-glycerophosphate sodium as the crosslinking agent and tannic acid (TA) as the drug model. The construction was realized through the synergistic effects of chemical crosslinking, electrostatic interaction, host-guest interaction, hydrogen bonding interaction, as well as supramolecular assembly driven by multiple interaction. Influence of various factors on the gelation time was investigated, and the properties of swelling, adsorption, rheology, antioxidant, drug-controlled release, antibacterial, and biocompatibility were systematically evaluated. Under optimal conditions, the gelation time of the cyclodextrin supramolecular hydrogel was 18 s, and the adsorption capacity for TA reached 315.2 mg/g, achieving controlled, sustained and long-lasting release. When the concentration of the drug-loaded gel reached 25 µg/mL, the DPPH radical scavenging rate was 91.9%, indicating excellent antioxidant properties. The antibacterial rates against Escherichia coli and Staphylococcus aureus were 98.4% and 98.9%, respectively, demonstrating good antibacterial performance. The cytotoxicity was grade 0, indicating good biocompatibility. Based on the in vitro evaluation results, this cyclodextrin-based supramolecular hydrogel shows promising potential as a wound dressing for the treatment of difficult-to-heal wounds, providing a feasible candidate for the development of novel medical dressing in the medical field.