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<p>Panax notoginseng saponins (PNS) is a natural medicine known for its ability to promote blood circulation, remove blood stasis, reduce swelling, and relieve pain. However, obtaining high-purity PNS from the crude extract of the medicinal plant Sanqi is a challenging and important task. In this study, a novel rosin-based diatomite polymer microsphere (RDPMs) was synthesized, and its physical and chemical properties were characterized using various analytical techniques. The adsorption capacity of RDPMs for PNS was 273.69&#xa0;mg·g<sup>−1</sup>, with an increase in PNS content from 44.38 to 79.59%. The process was spontaneous, endothermic, and multilayered, controlled by physical and chemical factors. Quantum chemical calculations revealed that there are <i>van der Waals forces</i>, H-bonding, and electrostatic interactions between RDPMs and PNS. Overall, RDPMs is an effective and reusable bioadsorbent with potential for isolating PNS from Sanqi extract.</p> Graphical Abstract <p></p>

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Separation and purification of PNS from Sanqi extract by a rosin-based polymer microsphere

  • 期刊论文

  • 发表日期：

    2025年6月19日

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  • Zhenfang Zeng,
  • Wei Wei,
  • Wen Li,
  • Hao Li,
  • Mengling Wei,
  • Zheng He,
  • Wenkun Huang,
  • Fuhou Lei

摘要

Panax notoginseng saponins (PNS) is a natural medicine known for its ability to promote blood circulation, remove blood stasis, reduce swelling, and relieve pain. However, obtaining high-purity PNS from the crude extract of the medicinal plant Sanqi is a challenging and important task. In this study, a novel rosin-based diatomite polymer microsphere (RDPMs) was synthesized, and its physical and chemical properties were characterized using various analytical techniques. The adsorption capacity of RDPMs for PNS was 273.69 mg·g−1, with an increase in PNS content from 44.38 to 79.59%. The process was spontaneous, endothermic, and multilayered, controlled by physical and chemical factors. Quantum chemical calculations revealed that there are van der Waals forces, H-bonding, and electrostatic interactions between RDPMs and PNS. Overall, RDPMs is an effective and reusable bioadsorbent with potential for isolating PNS from Sanqi extract.

Graphical Abstract