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Purpose <p>Many individuals turn to supplements like magnesium, believing them to offer a natural way to improve sleep quality. Yet, research on magnesium’s effects has produced inconsistent results. We assessed the relationships between magnesium supplementation and subjective/ or objective sleep parameters, including night cramps.</p> Methods <p>Data from three follow-ups of the population based CoLaus|PsyColaus cohort: 2009–12 (first), 2014–17 (second), and 2018–21 (third). Magnesium supplement use was self-reported, and participants were categorized either as users or non-users. Subjective sleep parameters were measured through questionnaires, and objective sleep parameters with polysomnography. The researchers computed a polygenic risk score (PRS) including five single nucleotide polymorphisms related to magnesium levels.</p> Results <p>The number and characteristics of the participants in the first, second, and third follow-ups were 3887 (52.6% women, 57.2 ± 10.4&#xa0;years, 4.5% magnesium users), 1916 (49.7% women, 60.8 ± 9.4&#xa0;years, 7.9% users), and 1561 (51.2% women, 63.1 ± 8.9&#xa0;years, 7.5% users), respectively. The multivariable-adjusted analyses indicated that magnesium users had a higher likelihood of experiencing night cramps or restless leg syndrome, with a trend towards poorer sleep quality. Multivariable-adjusted analyses revealed no significant differences between participants with and without cramps regarding polysomnography results or magnesium PRS. The prospective analyses demonstrated that participants taking magnesium supplements at baseline had a higher incidence of night cramps. The incidence of restless leg syndrome did not differ between users and non-users.</p> Conclusion <p>We found no consistent association between magnesium supplementation and subjective or objective sleep parameters or restless leg syndrome. Magnesium supplementation did not prevent night cramps.</p> Graphical abstract <p></p>

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Magnesium supplements, sleep quality, and nocturnal leg cramps: a combination of cross-sectional and prospective studies

  • 期刊论文

  • 发表日期：

    2026年2月16日

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  • Noelle Stadie,
  • Raphaël Heinzer,
  • Pedro Marques-Vidal

摘要

Purpose

Many individuals turn to supplements like magnesium, believing them to offer a natural way to improve sleep quality. Yet, research on magnesium’s effects has produced inconsistent results. We assessed the relationships between magnesium supplementation and subjective/ or objective sleep parameters, including night cramps.

Methods

Data from three follow-ups of the population based CoLaus|PsyColaus cohort: 2009–12 (first), 2014–17 (second), and 2018–21 (third). Magnesium supplement use was self-reported, and participants were categorized either as users or non-users. Subjective sleep parameters were measured through questionnaires, and objective sleep parameters with polysomnography. The researchers computed a polygenic risk score (PRS) including five single nucleotide polymorphisms related to magnesium levels.

Results

The number and characteristics of the participants in the first, second, and third follow-ups were 3887 (52.6% women, 57.2 ± 10.4 years, 4.5% magnesium users), 1916 (49.7% women, 60.8 ± 9.4 years, 7.9% users), and 1561 (51.2% women, 63.1 ± 8.9 years, 7.5% users), respectively. The multivariable-adjusted analyses indicated that magnesium users had a higher likelihood of experiencing night cramps or restless leg syndrome, with a trend towards poorer sleep quality. Multivariable-adjusted analyses revealed no significant differences between participants with and without cramps regarding polysomnography results or magnesium PRS. The prospective analyses demonstrated that participants taking magnesium supplements at baseline had a higher incidence of night cramps. The incidence of restless leg syndrome did not differ between users and non-users.

Conclusion

We found no consistent association between magnesium supplementation and subjective or objective sleep parameters or restless leg syndrome. Magnesium supplementation did not prevent night cramps.

Graphical abstract