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Background <p>Metabolic dysfunction associated steatotic liver disease (MASLD) is the most common liver disease threatening public health. Quercetin is considered a promising candidate for treating and preventing MASLD, due to its antioxidant and anti-inflammatory properties. However, few studies have evaluated the association of daily quercetin intake with the risk of MASLD in the general population.</p> Methods <p>This prospective cohort study included 16,746 adults. Dietary quercetin intake was assessed using a validated food frequency questionnaire. Incident MASLD cases were ascertained annually by liver ultrasound and cardiometabolic risk factors. Multivariable Cox proportional-hazards models were used to evaluate the association between quercetin intake and the risk of MASLD.</p> Results <p>The data from 16,746 participants, with an average follow-up time of approximately 3.47&#xa0;years, were analyzed and 3,544 participants developed MASLD during follow-up. After Multivariable adjustment, the hazard ratio (95% confidence interval) for MASLD across increasing quartiles of quercetin intake was 1.00 (reference), 0.93 (0.85, 1.03), 1.01 (0.91, 1.12), and 1.04 (0.92, 1.17) (<i>P</i> for trend = 0.35). Similarly, the adjusted hazard ratio (95% confidence interval) for MASLD across increasing quartiles of energy density and per-unit-kilogram-body-weight intake was 1.00 (reference), 0.99 (0.89, 1.09), 0.98 (0.89, 1.09), 1.02 (0.92, 1.13) (<i>P</i> for trend = 0.77), and 1.00 (reference), 0.92 (0.84, 1.01), 0.92 (0.83, 1.02), 0.94 (0.83, 1.06) (<i>P</i> for trend = 0.29), respectively.</p> Conclusion <p>No association was observed between dietary quercetin intake and the incidence of MASLD. The findings of this study need to be confirmed in other populations.</p>

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Dietary quercetin intake is not associated with risk of metabolic dysfunction-associated steatotic liver disease in a general adult population

  • 期刊论文

  • 发表日期：

    2025年7月22日

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  • Juanjuan Liu,
  • Hongmei Wu,
  • Yeqing Gu,
  • Ge Meng,
  • Xuehui Wu,
  • Dandan Zhu,
  • Qing Zhang,
  • Li Liu,
  • Sizhen Lai,
  • Yinxiao Chen,
  • Dongli Wang,
  • Shaomei Sun,
  • Xing Wang,
  • Qiyu Jia,
  • Kun Song,
  • Kaijun Niu

摘要

Background

Metabolic dysfunction associated steatotic liver disease (MASLD) is the most common liver disease threatening public health. Quercetin is considered a promising candidate for treating and preventing MASLD, due to its antioxidant and anti-inflammatory properties. However, few studies have evaluated the association of daily quercetin intake with the risk of MASLD in the general population.

Methods

This prospective cohort study included 16,746 adults. Dietary quercetin intake was assessed using a validated food frequency questionnaire. Incident MASLD cases were ascertained annually by liver ultrasound and cardiometabolic risk factors. Multivariable Cox proportional-hazards models were used to evaluate the association between quercetin intake and the risk of MASLD.

Results

The data from 16,746 participants, with an average follow-up time of approximately 3.47 years, were analyzed and 3,544 participants developed MASLD during follow-up. After Multivariable adjustment, the hazard ratio (95% confidence interval) for MASLD across increasing quartiles of quercetin intake was 1.00 (reference), 0.93 (0.85, 1.03), 1.01 (0.91, 1.12), and 1.04 (0.92, 1.17) (P for trend = 0.35). Similarly, the adjusted hazard ratio (95% confidence interval) for MASLD across increasing quartiles of energy density and per-unit-kilogram-body-weight intake was 1.00 (reference), 0.99 (0.89, 1.09), 0.98 (0.89, 1.09), 1.02 (0.92, 1.13) (P for trend = 0.77), and 1.00 (reference), 0.92 (0.84, 1.01), 0.92 (0.83, 1.02), 0.94 (0.83, 1.06) (P for trend = 0.29), respectively.

Conclusion

No association was observed between dietary quercetin intake and the incidence of MASLD. The findings of this study need to be confirmed in other populations.