Scholarlink

Purpose <p>Adequate maternal iodine status is essential for healthy foetal brain development. There are no current data on maternal iodine status in Ireland. The aim of this study was to conduct the first large-scale assessment of maternal iodine status in Ireland and identify its sociodemographic determinants using data from a large prospective pregnancy cohort.</p> Methods <p>Participants were nulliparous females (<i>n</i> = 1509) recruited at Cork University Maternity Hospital, Cork, Ireland. Clinical and questionnaire-based assessments were carried out and spot urine samples were collected throughout pregnancy. Urinary iodine concentration (UIC) at 11 and 15 weeks of gestation was quantified using the Sandell–Kolthoff colorimetric method. UIC was corrected for urinary creatinine (measured via Jaffe assay), expressed as I: Cr ratio. Linear and logistic regression were performed to identify non-dietary determinants of iodine status in early pregnancy.</p> Results <p>Median (IQR) UIC at 11 and 15 weeks of gestation were 128 (76, 201) and 125 (74, 208) µg/L, respectively, indicating mild-to-moderate iodine deficiency during pregnancy at both timepoints. Iodine-containing supplement use, winter season, BMI, age and education were predictors of I: Cr &lt; 150&#xa0;µg/g.</p> Conclusion <p>This first large-scale investigation of maternal iodine status in Ireland highlighted sub-optimal status in pregnancy.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Mild-to-moderate iodine deficiency among pregnant women in Ireland: data from a large prospective pregnancy cohort

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年5月9日

查看全文
  • Lisa Kelliher,
  • Mairead E. Kiely,
  • Jillian R.-M. Browne,
  • Yvonne C. O’Callaghan,
  • Áine Hennessy

摘要

Purpose

Adequate maternal iodine status is essential for healthy foetal brain development. There are no current data on maternal iodine status in Ireland. The aim of this study was to conduct the first large-scale assessment of maternal iodine status in Ireland and identify its sociodemographic determinants using data from a large prospective pregnancy cohort.

Methods

Participants were nulliparous females (n = 1509) recruited at Cork University Maternity Hospital, Cork, Ireland. Clinical and questionnaire-based assessments were carried out and spot urine samples were collected throughout pregnancy. Urinary iodine concentration (UIC) at 11 and 15 weeks of gestation was quantified using the Sandell–Kolthoff colorimetric method. UIC was corrected for urinary creatinine (measured via Jaffe assay), expressed as I: Cr ratio. Linear and logistic regression were performed to identify non-dietary determinants of iodine status in early pregnancy.

Results

Median (IQR) UIC at 11 and 15 weeks of gestation were 128 (76, 201) and 125 (74, 208) µg/L, respectively, indicating mild-to-moderate iodine deficiency during pregnancy at both timepoints. Iodine-containing supplement use, winter season, BMI, age and education were predictors of I: Cr < 150 µg/g.

Conclusion

This first large-scale investigation of maternal iodine status in Ireland highlighted sub-optimal status in pregnancy.