Scholarlink

<p>Inflammatory rheumatic diseases, such as rheumatoid arthritis (RA), are characterized by local and systemic bone demineralization. Local demineralization is manifested in the periarticular region of the inflamed joints, particularly at the metacarpophalangeal and metatarsophalangeal joints. Local demineralization shows a significant correlation with inflammatory activity, whereas systemic osteoporosis, predominantly affecting the spine and hip, is typically associated with a&#xa0;prolonged disease duration, glucocorticoid treatment and immobilization. The receptor activator of the nuclear factor-kB ligand (RANKL)/osteoprotegerin (OPG) system and the Wnt signaling pathway play a&#xa0;pivotal role in regulating bone metabolism and are themselves negatively influenced by inflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha) and interleukin (IL)-6. The diagnostics include both imaging procedures and procedures for bone mineral density measurement, employing techniques such as high-resolution peripheral quantitative computed tomography (HR-pQCT) and dual energy X‑ray absorptiometry (DXA). These are used for quantification of the bone mineral density. The objective of therapeutic approaches is to reduce disease activity and modulate signaling pathways in order to slow down demineralization and reduce the risk of fractures.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Systemische versus lokale Demineralisation bei der rheumatoiden Arthritis

  • 期刊论文

  • 发表日期：

    2025年2月11日

查看全文
  • Tobias Hoffmann,
  • Carolin Pflug,
  • Wiebke Schulze,
  • Alexander Pfeil

摘要

Inflammatory rheumatic diseases, such as rheumatoid arthritis (RA), are characterized by local and systemic bone demineralization. Local demineralization is manifested in the periarticular region of the inflamed joints, particularly at the metacarpophalangeal and metatarsophalangeal joints. Local demineralization shows a significant correlation with inflammatory activity, whereas systemic osteoporosis, predominantly affecting the spine and hip, is typically associated with a prolonged disease duration, glucocorticoid treatment and immobilization. The receptor activator of the nuclear factor-kB ligand (RANKL)/osteoprotegerin (OPG) system and the Wnt signaling pathway play a pivotal role in regulating bone metabolism and are themselves negatively influenced by inflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha) and interleukin (IL)-6. The diagnostics include both imaging procedures and procedures for bone mineral density measurement, employing techniques such as high-resolution peripheral quantitative computed tomography (HR-pQCT) and dual energy X‑ray absorptiometry (DXA). These are used for quantification of the bone mineral density. The objective of therapeutic approaches is to reduce disease activity and modulate signaling pathways in order to slow down demineralization and reduce the risk of fractures.