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Background <p>Noise pollution is increasingly recognized as a cardiovascular hazard, yet its contribution to early-onset myocardial infarction (EOMI) has not yet been investigated before.</p> Methods <p>This study included patients aged ≤ 50&#xa0;years with myocardial infarction (MI) who were admitted to the Heart Center Bremen/Germany between 2015 and 2023. Based on traditional risk factors at the time of the index MI, the 10-year cardiovascular risk was estimated using the LIFE-CVD model. Residential noise exposure levels were extracted from the municipal GeoPortal.</p> Results <p>In this study involving 430 young MI patients, the mean age was 45 ± 5&#xa0;years, and 85.8% were male. Compared with low-noise peers, high-noise patients smoked less (31% vs. 54%), had fewer first-degree relatives with MI (18% vs. 34%), and less diabetes (6% vs. 12%; all <i>p</i> &lt; 0.05). The average noise exposure increased as traditional risk factor exposure decreased (ANOVA <i>p</i> &lt; 0.001 for LIFE-CVD score vs. noise exposure); this inverse association remained even after adjustment in multivariable analysis. In multivariable linear regression, higher noise exposure category was associated with a younger age at first MI (<i>β</i> = − 0.43&#xa0;years per category; 95% CI − 0.74 to − 0.12; <i>p</i> &lt; 0.01).</p> Conclusion <p>Among patients with EOMI and few traditional risk factors, elevated residential noise exposure was observed. Higher noise exposure was also associated with a younger age at first MI. These findings are hypothesis-generating and warrant further population-based studies to clarify whether residential noise contributes to MI risk and whether objectively assessed noise metrics could strengthen prevention strategies.</p> Graphical Abstract <p></p>

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Impact of residential noise pollution on early-onset myocardial infarction risk results from the DECIBEL-MI (Determination of Environmental CIty-noise's Burden, Exposure, and Link to Myocardial Infarction) study

  • 期刊论文

  • 发表日期：

    2026年3月30日

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  • Hatim Kerniss,
  • Stephan Rühle,
  • Kilian Clemens,
  • Ulrich Hanses,
  • Johannes Schmucker,
  • Rico Osteresch,
  • Andreas Fach,
  • Rainer Hambrecht,
  • Harm Wienbergen

摘要

Background

Noise pollution is increasingly recognized as a cardiovascular hazard, yet its contribution to early-onset myocardial infarction (EOMI) has not yet been investigated before.

Methods

This study included patients aged ≤ 50 years with myocardial infarction (MI) who were admitted to the Heart Center Bremen/Germany between 2015 and 2023. Based on traditional risk factors at the time of the index MI, the 10-year cardiovascular risk was estimated using the LIFE-CVD model. Residential noise exposure levels were extracted from the municipal GeoPortal.

Results

In this study involving 430 young MI patients, the mean age was 45 ± 5 years, and 85.8% were male. Compared with low-noise peers, high-noise patients smoked less (31% vs. 54%), had fewer first-degree relatives with MI (18% vs. 34%), and less diabetes (6% vs. 12%; all p < 0.05). The average noise exposure increased as traditional risk factor exposure decreased (ANOVA p < 0.001 for LIFE-CVD score vs. noise exposure); this inverse association remained even after adjustment in multivariable analysis. In multivariable linear regression, higher noise exposure category was associated with a younger age at first MI (β = − 0.43 years per category; 95% CI − 0.74 to − 0.12; p < 0.01).

Conclusion

Among patients with EOMI and few traditional risk factors, elevated residential noise exposure was observed. Higher noise exposure was also associated with a younger age at first MI. These findings are hypothesis-generating and warrant further population-based studies to clarify whether residential noise contributes to MI risk and whether objectively assessed noise metrics could strengthen prevention strategies.

Graphical Abstract