Scholarlink

Background <p>Takotsubo syndrome (TS) and STEMI with timely reperfusion are both characterized by reversible acute myocardial dysfunction, often referred to as myocardial stunning. The natural course of cardiac functional recovery is incompletely understood in TS and STEMI. The aim of this study was to prospectively compare changes in cardiac function over the acute and subacute phases in women with TS versus anterior STEMI.</p> Methods <p>The Stunning in Takotsubo versus Acute Myocardial Infarction (STAMI) study prospectively enrolled 61 women with TS and 41 women with STEMI. Echocardiography and blood sampling was performed within 4&#xa0;h of admission and at 1, 2, 3, 7, 14, and 30&#xa0;days after admission. The primary outcome was the proportion of reversible left ventricular akinesia (defined as extent of akinesia at baseline versus at 30&#xa0;days) that resolved by 72&#xa0;h. Secondary outcomes included LVEF, GLS, and TAPSE. Mixed effects linear regression or mixed effects tobit models with random intercepts were used to model echocardiographic parameters over time.</p> Results <p>At 72&#xa0;h 40.4% [95% CI 30.1%, 50.1%] of the reversible akinesia had resolved in women with TS, versus 54.7% [95% CI 38.3%, 72.0%] for STEMI (difference 14.3% [95% CI −&#xa0;4.6%, 34.3%]). Time-course of recovery of LVEF and GLS was also similar in TS and STEMI. TAPSE was reduced in TS but normal in STEMI; and recovered in a similar timeframe as the left ventricular indices. In both TS and STEMI, considerable recovery of cardiac function occurred after 7&#xa0;days.</p> Conclusions <p>The time course of recovery of cardiac function is similar in TS and STEMI.</p> Trial registration <p>ClinicalTrials.gov ID NCT04448639, <a href="https://clinicaltrials.gov/study/NCT04448639">https://clinicaltrials.gov/study/NCT04448639</a>.</p> Graphical abstract <p>The stunning in Takotsubo versus acute myocardial infarction (STAMI) study compared the changes in cardiac function over time in 61 women with takotsubo syndrome (TS) versus 41 women with ST elevation myocardial infarction (STEMI) over a 30-day period. The time course of cardiac recovery was similar in takotsubo and anterior ST-elevation myocardial infarction. In both takotsubo and ST-elevation myocardial infarction, recovery of cardiac function takes on average longer than 7 days.</p> <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Prospective comparison of temporal changes in myocardial function in women with Takotsubo versus anterior STEMI

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年3月20日

查看全文
  • Sandeep Jha,
  • Angela Poller,
  • Aaron Shekka Espinosa,
  • Linnea Molander,
  • Valentyna Sevastianova,
  • Rickard Zeijlon,
  • Koen Simons,
  • Emanuele Bobbio,
  • Carlo Pirazzi,
  • Andreas Martinsson,
  • Tomas Mellberg,
  • Thorsteinn Gudmundsson,
  • Petronella Torild,
  • Joakim Sundstrom,
  • Erik Axel Andersson,
  • Sigurdur Thorleifsson,
  • Sabin Salahuddin,
  • Ahmed Elmahdy,
  • Tetiana Pylova,
  • Araz Rawshani,
  • Oskar Angeras,
  • Truls Ramunddal,
  • Kristofer Skoglund,
  • Elmir Omerovic,
  • Bjorn Redfors

摘要

Background

Takotsubo syndrome (TS) and STEMI with timely reperfusion are both characterized by reversible acute myocardial dysfunction, often referred to as myocardial stunning. The natural course of cardiac functional recovery is incompletely understood in TS and STEMI. The aim of this study was to prospectively compare changes in cardiac function over the acute and subacute phases in women with TS versus anterior STEMI.

Methods

The Stunning in Takotsubo versus Acute Myocardial Infarction (STAMI) study prospectively enrolled 61 women with TS and 41 women with STEMI. Echocardiography and blood sampling was performed within 4 h of admission and at 1, 2, 3, 7, 14, and 30 days after admission. The primary outcome was the proportion of reversible left ventricular akinesia (defined as extent of akinesia at baseline versus at 30 days) that resolved by 72 h. Secondary outcomes included LVEF, GLS, and TAPSE. Mixed effects linear regression or mixed effects tobit models with random intercepts were used to model echocardiographic parameters over time.

Results

At 72 h 40.4% [95% CI 30.1%, 50.1%] of the reversible akinesia had resolved in women with TS, versus 54.7% [95% CI 38.3%, 72.0%] for STEMI (difference 14.3% [95% CI − 4.6%, 34.3%]). Time-course of recovery of LVEF and GLS was also similar in TS and STEMI. TAPSE was reduced in TS but normal in STEMI; and recovered in a similar timeframe as the left ventricular indices. In both TS and STEMI, considerable recovery of cardiac function occurred after 7 days.

Conclusions

The time course of recovery of cardiac function is similar in TS and STEMI.

Trial registration

ClinicalTrials.gov ID NCT04448639, https://clinicaltrials.gov/study/NCT04448639.

Graphical abstract

The stunning in Takotsubo versus acute myocardial infarction (STAMI) study compared the changes in cardiac function over time in 61 women with takotsubo syndrome (TS) versus 41 women with ST elevation myocardial infarction (STEMI) over a 30-day period. The time course of cardiac recovery was similar in takotsubo and anterior ST-elevation myocardial infarction. In both takotsubo and ST-elevation myocardial infarction, recovery of cardiac function takes on average longer than 7 days.