Scholarlink

<p>Intercellular communication refers to the various ways through which cells communicate with one another and exchange a&#xa0;wide range of messages. Aging leads to a&#xa0;shift from coordinated signal transmission to disrupted, uncoordinated communication, which is primarily caused by senescent cells and their secretome (senescence-associated secretory phenotype, SASP). This breakdown drives systemic aging and leads to dysfunction and inflammatory processes throughout the body. A&#xa0;translational approach now involves either reducing the number of senescent cells using senolytics or inhibiting their SASP using senomorphics. This approach, which has been successful in animal studies, is now to be translated to humans.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Fehlgeleitete interzelluläre Kommunikation beim Altern und bei chronischen Entzündungen

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月22日

查看全文
  • Anne Großkopf,
  • Lars Saemann,
  • Andreas Simm

摘要

Intercellular communication refers to the various ways through which cells communicate with one another and exchange a wide range of messages. Aging leads to a shift from coordinated signal transmission to disrupted, uncoordinated communication, which is primarily caused by senescent cells and their secretome (senescence-associated secretory phenotype, SASP). This breakdown drives systemic aging and leads to dysfunction and inflammatory processes throughout the body. A translational approach now involves either reducing the number of senescent cells using senolytics or inhibiting their SASP using senomorphics. This approach, which has been successful in animal studies, is now to be translated to humans.