Scholarlink

Background <p>This study investigated the detrimental effects of a&#xa0;high anticholinergic burden on both myocardial systolic-diastolic functions and electrical functions in older adults.</p> Methods <p>A&#xa0;total of 24&#xa0;patients with a&#xa0;high anticholinergic burden and 26&#xa0;control patients were enrolled. The anticholinergic burden was assessed using the anticholinergic burden (ACB) scale. An ACB of ≥ 2 was categorized as high anticholinergic burden, while those with an ACB score of&#xa0;0 were included in the control group. Each participant’s diastolic and systolic functions were evaluated using transthoracic two-dimensional, conventional and tissue Doppler echocardiography. Heart rate and corrected QT interval (cQT) were also measured to assess electrophysiological changes.</p> Results <p>The mean age was 72.5 ± 6.6&#xa0;years. Biventricular systolic and diastolic functions were impaired in the high ACB patients. Systolic function parameters such as lateral‑S (8.04 ± 1.43 vs. 9.54 ± 1.82, <i>p</i> = 0.003), septal‑S (7.33 ± 0.64 vs. 8.27 ± 1.31, <i>p</i> = 0.007) and tricuspid‑S (12.42 ± 1.72 vs. 14.31 ± 3.17, <i>p</i> = 0.025) values were lower in the ACB patients compared to the control group. The indicator of left ventricular (LV) filling pressure (E/E’) was higher in ACB patients than in the controls (11.61 ± 2.89 vs. 8.83 ± 1.68, <i>p</i> &lt; 0.001). There was no significant difference in terms of heart rate and cQT. Serum albumin levels were lower in ACB patients comparing to controls (4.08 ± 0.33 vs. 4.38 ± 0.27, <i>p</i> = 0.001).</p> Conclusion <p>A&#xa0;high anticholinergic burden is associated with moderately impaired systolic and diastolic functions, yet on its own, it does not sufficiently explain the increased hospitalization and mortality observed in older adults.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Effect of anticholinergic burden on cardiac functions in older patients

  • 期刊论文

  • 发表日期：

    2026年7月1日

查看全文
  • Hakan Fotbolcu,
  • Pınar Soysal

摘要

Background

This study investigated the detrimental effects of a high anticholinergic burden on both myocardial systolic-diastolic functions and electrical functions in older adults.

Methods

A total of 24 patients with a high anticholinergic burden and 26 control patients were enrolled. The anticholinergic burden was assessed using the anticholinergic burden (ACB) scale. An ACB of ≥ 2 was categorized as high anticholinergic burden, while those with an ACB score of 0 were included in the control group. Each participant’s diastolic and systolic functions were evaluated using transthoracic two-dimensional, conventional and tissue Doppler echocardiography. Heart rate and corrected QT interval (cQT) were also measured to assess electrophysiological changes.

Results

The mean age was 72.5 ± 6.6 years. Biventricular systolic and diastolic functions were impaired in the high ACB patients. Systolic function parameters such as lateral‑S (8.04 ± 1.43 vs. 9.54 ± 1.82, p = 0.003), septal‑S (7.33 ± 0.64 vs. 8.27 ± 1.31, p = 0.007) and tricuspid‑S (12.42 ± 1.72 vs. 14.31 ± 3.17, p = 0.025) values were lower in the ACB patients compared to the control group. The indicator of left ventricular (LV) filling pressure (E/E’) was higher in ACB patients than in the controls (11.61 ± 2.89 vs. 8.83 ± 1.68, p < 0.001). There was no significant difference in terms of heart rate and cQT. Serum albumin levels were lower in ACB patients comparing to controls (4.08 ± 0.33 vs. 4.38 ± 0.27, p = 0.001).

Conclusion

A high anticholinergic burden is associated with moderately impaired systolic and diastolic functions, yet on its own, it does not sufficiently explain the increased hospitalization and mortality observed in older adults.