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Purpose <p>Colorectal cancer (CRC) is the third most prevalent cancer worldwide, showing an increasing early-onset CRC in patients, which is defined as diagnoses made before the age of 50. Studies conflict on early-onset CRC prognosis versus late-onset CRC with varying survival outcomes. This study explores the age-related survival differences in colon cancer by comparing early- and late-onset groups.</p> Methods <p>We performed a retrospective cohort study at a tertiary referral hospital (2010–2018), including 3459 patients with colon cancer (3076 late-onset, 383 early-onset). The clinicopathological features of early- and late-onset colon cancer were compared, and cancer-specific survival was evaluated using the Kaplan–Meier analysis with log-rank tests. The multivariate Cox regression identified independent prognostic factors.</p> Results <p>Early-onset colon cancer showed female predominance, better Eastern Cooperative Oncology Group performance, more left-sided tumors, and advanced stages. On the contrary, late-onset patients had worse cancer-specific survival (hazard ratio 1.506, 95% confidence interval 1.147–1.977, <i>p</i> = 0.003), particularly in stages II/III, with tumor perforation, signet ring cells, or no perineural invasion.</p> Conclusion <p>In conclusion, despite early-onset colon cancer exhibiting more aggressive features, it is associated with better survival compared with late-onset cases. Further studies are required to validate these findings.</p>

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Early- vs. late-onset colon cancer: clinicopathological insights and survival outcomes in an East Asian cohort

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月9日

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  • Chun-Chi Lin,
  • Che-Yuan Chang,
  • Yu-Zu Lin,
  • Hou-Hsuan Cheng,
  • Sheng-Chieh Huang,
  • Hung-Hsin Lin,
  • Yuan-Tzu Lan,
  • Huann-Sheng Wang,
  • Shih-Ching Chang,
  • Shung-Haur Yang,
  • Jeng-Kai Jiang,
  • Wei-Shone Chen,
  • Hao-Wei Teng,
  • Yi-Wen Yang

摘要

Purpose

Colorectal cancer (CRC) is the third most prevalent cancer worldwide, showing an increasing early-onset CRC in patients, which is defined as diagnoses made before the age of 50. Studies conflict on early-onset CRC prognosis versus late-onset CRC with varying survival outcomes. This study explores the age-related survival differences in colon cancer by comparing early- and late-onset groups.

Methods

We performed a retrospective cohort study at a tertiary referral hospital (2010–2018), including 3459 patients with colon cancer (3076 late-onset, 383 early-onset). The clinicopathological features of early- and late-onset colon cancer were compared, and cancer-specific survival was evaluated using the Kaplan–Meier analysis with log-rank tests. The multivariate Cox regression identified independent prognostic factors.

Results

Early-onset colon cancer showed female predominance, better Eastern Cooperative Oncology Group performance, more left-sided tumors, and advanced stages. On the contrary, late-onset patients had worse cancer-specific survival (hazard ratio 1.506, 95% confidence interval 1.147–1.977, p = 0.003), particularly in stages II/III, with tumor perforation, signet ring cells, or no perineural invasion.

Conclusion

In conclusion, despite early-onset colon cancer exhibiting more aggressive features, it is associated with better survival compared with late-onset cases. Further studies are required to validate these findings.