Scholarlink

Purpose <p>The study aims to evaluate the correlation between visceral adiposity, fatty liver, and survival in patients with metastatic colorectal cancer (mCRC).</p> Methods <p>The study included 131 adult patients with treatment-naive mCRC. The visceral and liver fat content was measured using baseline computed tomography (CT) images. The analysis used the 50th percentile (131.80 HU) visceral adiposity value as a cutoff. The visceral and liver fat content association with patient characteristics and outcomes was assessed.</p> Results <p>In the overall cohort, neither visceral adiposity (median OS 37.8 vs 36.7&#xa0;months, HR = 0.83; <i>p</i> = 0.428) nor liver steatosis (median OS 46.0 vs 33.9&#xa0;months, HR = 0.81; <i>p</i> = 0.370) showed significant association with OS. However, in patients with BMI ≥ 25&#xa0;kg/m<sup>2</sup>, liver steatosis was associated with significantly shorter survival (median OS 35.2 vs 59.5&#xa0;months; adjusted HR = 0.49; <i>p</i> = 0.040). Visceral adiposity remained non-significant across BMI subgroups.</p> Conclusion <p>We observed a possible association between liver steatosis and OS in patients with mCRC in the high BMI subgroup. Prospective studies are essential to validate these findings and the role of liver steatosis in the prognostic assessment of mCRC patients.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Assessment of the correlation between visceral adiposity and liver fat in metastatic colorectal cancer patients

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月17日

查看全文
  • Cigdem Elif Celik,
  • Elvin Chalabiyev,
  • Volkan Gurler,
  • Mehmet Ruhi Onur,
  • Taha Koray Şahin,
  • Omer Dizdar,
  • Fusun Ozmen

摘要

Purpose

The study aims to evaluate the correlation between visceral adiposity, fatty liver, and survival in patients with metastatic colorectal cancer (mCRC).

Methods

The study included 131 adult patients with treatment-naive mCRC. The visceral and liver fat content was measured using baseline computed tomography (CT) images. The analysis used the 50th percentile (131.80 HU) visceral adiposity value as a cutoff. The visceral and liver fat content association with patient characteristics and outcomes was assessed.

Results

In the overall cohort, neither visceral adiposity (median OS 37.8 vs 36.7 months, HR = 0.83; p = 0.428) nor liver steatosis (median OS 46.0 vs 33.9 months, HR = 0.81; p = 0.370) showed significant association with OS. However, in patients with BMI ≥ 25 kg/m2, liver steatosis was associated with significantly shorter survival (median OS 35.2 vs 59.5 months; adjusted HR = 0.49; p = 0.040). Visceral adiposity remained non-significant across BMI subgroups.

Conclusion

We observed a possible association between liver steatosis and OS in patients with mCRC in the high BMI subgroup. Prospective studies are essential to validate these findings and the role of liver steatosis in the prognostic assessment of mCRC patients.