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Purpose <p>To evaluate the efficacy of injection sclerotherapy in the management of reducible rectal prolapse (RP) in children.</p> Methods <p>Children with reducible RP who underwent sclerotherapy with Kinurea-H<sup>®</sup> (quinine dihydrochloride/urea) were retrospectively included, and divided into 2 groups, functional RP (FRP) or organic RP (ORP).</p> Results <p>Thirty-two patients were included, 18 FRP and 14 ORP (7 anorectal malformation (ARM), 2 anorexia nervosa, 1 Hirschsprung disease, 2 spinal dysraphism, 1 Ehlers-Danlos, 1 short bowel syndrome) with a median age of 4 years. After one injection, the success rate was higher in FRP (78%) than in ORP (21%) (<i>p</i> = 0.0009). After 2–4 injections, success rate was 94% in FRP and 93% in ORP, with a minimal mucosal resection of the fixed portion (less than 5&#xa0;mm, limited to the ano-cutaneous junction) in 4/7 ARM. Repeated injections were performed at same site in all ORP without ARM, and in only 43% of ORP with ARM. Recurrence of reducible RP after the first injection at one site was associated with ORP (<i>p</i> = 0.03), particularly in ORP without ARM (<i>p</i> = 0.06).</p> Conclusion <p>Sclerotherapy for reducible RP is efficient after failure of conservative management in FRP and success rate after repeated injections is encouraging in ORP, particularly in ARM.</p>

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Sclerotherapy as first-line treatment of rectal prolapse in children, including those with anorectal malformations

  • 期刊论文

  • 发表日期：

    2025年12月27日

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  • Anne Dariel,
  • Eliane El Khoury,
  • Matthieu Charbonnier,
  • Jessica Pinol,
  • Mathieu Rouy,
  • Alice Faure,
  • Nicoleta Panait,
  • Claude Borrione

摘要

Purpose

To evaluate the efficacy of injection sclerotherapy in the management of reducible rectal prolapse (RP) in children.

Methods

Children with reducible RP who underwent sclerotherapy with Kinurea-H® (quinine dihydrochloride/urea) were retrospectively included, and divided into 2 groups, functional RP (FRP) or organic RP (ORP).

Results

Thirty-two patients were included, 18 FRP and 14 ORP (7 anorectal malformation (ARM), 2 anorexia nervosa, 1 Hirschsprung disease, 2 spinal dysraphism, 1 Ehlers-Danlos, 1 short bowel syndrome) with a median age of 4 years. After one injection, the success rate was higher in FRP (78%) than in ORP (21%) (p = 0.0009). After 2–4 injections, success rate was 94% in FRP and 93% in ORP, with a minimal mucosal resection of the fixed portion (less than 5 mm, limited to the ano-cutaneous junction) in 4/7 ARM. Repeated injections were performed at same site in all ORP without ARM, and in only 43% of ORP with ARM. Recurrence of reducible RP after the first injection at one site was associated with ORP (p = 0.03), particularly in ORP without ARM (p = 0.06).

Conclusion

Sclerotherapy for reducible RP is efficient after failure of conservative management in FRP and success rate after repeated injections is encouraging in ORP, particularly in ARM.