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Objective <p>To evaluate early outcomes of infants with gastroschisis managed at a UK tertiary centre over 16&#xa0;years, focusing on associations between maternal factors, closure techniques, and postoperative outcomes.</p> Methods <p>A retrospective cohort study included 126 live-born infants with intra-operatively confirmed gastroschisis (June 2008–June 2024). Data on maternal demographics, perinatal factors, surgical management, and outcomes were collected. Multivariable logistic regression adjusted for gestational age, birth weight, gastroschisis complexity, and maternal smoking.</p> Results <p>Antenatal ultrasound identified 98% of cases. Median gestational age was 37&#xa0;weeks; mean birth weight was 2.4&#xa0;kg. Sutureless closure was used in 41% of cases and showed a trend toward earlier feeding and shorter hospital stay, though differences were not statistically significant. However, sutureless closure was associated with higher rates of sepsis (73% vs. 41%, p = 0.005) and hernia formation (42% vs. 22%, p = 0.01). Maternal smoking independently increased neonatal sepsis risk (adjusted OR 2.1, 95% CI 1.1–4.0). Overall survival was 96.8%, with all deaths occurring in complex cases.</p> Conclusion <p>While sutureless closure may offer perioperative advantages, it is associated with increased postoperative morbidity. Maternal smoking is a modifiable risk factor for neonatal sepsis. Individualised surgical approaches and targeted maternal interventions are recommended.</p>

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Maternal risk factors and closure techniques in gastroschisis: a 16-year retrospective review from a UK tertiary centre

  • 期刊论文

  • 发表日期：

    2025年11月4日

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  • A. Anand,
  • A. M. Masna,
  • A. Kulkarni,
  • A. Saeed,
  • Z. Mukhtar,
  • C. K. Sinha

摘要

Objective

To evaluate early outcomes of infants with gastroschisis managed at a UK tertiary centre over 16 years, focusing on associations between maternal factors, closure techniques, and postoperative outcomes.

Methods

A retrospective cohort study included 126 live-born infants with intra-operatively confirmed gastroschisis (June 2008–June 2024). Data on maternal demographics, perinatal factors, surgical management, and outcomes were collected. Multivariable logistic regression adjusted for gestational age, birth weight, gastroschisis complexity, and maternal smoking.

Results

Antenatal ultrasound identified 98% of cases. Median gestational age was 37 weeks; mean birth weight was 2.4 kg. Sutureless closure was used in 41% of cases and showed a trend toward earlier feeding and shorter hospital stay, though differences were not statistically significant. However, sutureless closure was associated with higher rates of sepsis (73% vs. 41%, p = 0.005) and hernia formation (42% vs. 22%, p = 0.01). Maternal smoking independently increased neonatal sepsis risk (adjusted OR 2.1, 95% CI 1.1–4.0). Overall survival was 96.8%, with all deaths occurring in complex cases.

Conclusion

While sutureless closure may offer perioperative advantages, it is associated with increased postoperative morbidity. Maternal smoking is a modifiable risk factor for neonatal sepsis. Individualised surgical approaches and targeted maternal interventions are recommended.