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Purpose <p>To evaluate the efficacy and safety of perioperative sodium bicarbonate Ringer's solution (BRS) in biliary atresia (BA) infants undergoing Kasai portoenterostomy (KPE).</p> Methods <p>This study was conducted in 11 pediatric medical centers across China from 2020 to 2022. Infants were randomly assigned to either the BRS group (n = 64) or the control crystalloids group (n = 56) for perioperative fluid management. Anesthesia and fluid management were standardized. Primary outcomes were arterial blood pH, bicarbonate, and base excess; secondary outcomes included changes in other blood parameters and adverse events.</p> Results <p>The baseline characteristics of the two groups were similar. During KPE, BRS more effectively maintained arterial blood pH, bicarbonate, and base excess during KPE with no electrolyte abnormalities. Three days after KPE, the BRS group had lower potassium levels. Drug safety evaluation showed no significant differences, and the incidence of adverse events was comparable.</p> Conclusion <p>BRS effectively maintained the acid–base status of BA infants during KPE. With no significant safety concerns, it is suggested that BRS is a suitable option for perioperative fluid management.</p>

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Efficacy of sodium bicarbonate Ringer’s solution for perioperative fluid management in infants with biliary atresia: a prospective multicenter study

  • 期刊论文

  • 发表日期：

    2025年4月9日

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  • Hongyi Zhang,
  • Pei Wang,
  • Ruohui Li,
  • Chonggao Zhou,
  • Kuai Chen,
  • Zhe Wen,
  • Yuanmei Liu,
  • Xiang Liu,
  • Qi Chen,
  • Jinfa Tou,
  • Hongxia Ren,
  • Mingman Zhang,
  • Feng Chen,
  • Jiexiong Feng

摘要

Purpose

To evaluate the efficacy and safety of perioperative sodium bicarbonate Ringer's solution (BRS) in biliary atresia (BA) infants undergoing Kasai portoenterostomy (KPE).

Methods

This study was conducted in 11 pediatric medical centers across China from 2020 to 2022. Infants were randomly assigned to either the BRS group (n = 64) or the control crystalloids group (n = 56) for perioperative fluid management. Anesthesia and fluid management were standardized. Primary outcomes were arterial blood pH, bicarbonate, and base excess; secondary outcomes included changes in other blood parameters and adverse events.

Results

The baseline characteristics of the two groups were similar. During KPE, BRS more effectively maintained arterial blood pH, bicarbonate, and base excess during KPE with no electrolyte abnormalities. Three days after KPE, the BRS group had lower potassium levels. Drug safety evaluation showed no significant differences, and the incidence of adverse events was comparable.

Conclusion

BRS effectively maintained the acid–base status of BA infants during KPE. With no significant safety concerns, it is suggested that BRS is a suitable option for perioperative fluid management.