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Background <p>Craniopharyngiomas are benign tumors with a challenging management due to the excessive morbidity of the classical therapeutic approaches. This has led to the current trend of a multimodal approach with more conservative surgical options.</p> Case report <p>We present the case of a 6-year old patient diagnosed with a giant multicystic and rapidly recurrent craniopharyngioma, showing the current trends towards a multimodal therapeutic approach with less aggressive surgical options. We emphasize the use of two different intracystic cycles of a new formulation of pegylated 2a interferon. We make a review of the available literature focusing on historical and current treatment options.</p> Conclusion <p>Craniopharyngiomas remain a challenge due to the morbidity caused by both the disease and its treatment. The current trend towards a more conservative approach has many alternative treatment options, with intracystic pegyladed 2a interferon being a safe and effective choice, even in consecutive administrations.</p>

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Case-based review: Craniopharyngioma treated with intracystic peginterferon

  • 期刊论文

  • 发表日期：

    2025年12月5日

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  • Gonzalo Nicolás Salagre,
  • Sara Iglesias,
  • María Isabel Martínez-León,
  • Marta Cortés,
  • Iván Federico Narváez,
  • Bienvenido Ros

摘要

Background

Craniopharyngiomas are benign tumors with a challenging management due to the excessive morbidity of the classical therapeutic approaches. This has led to the current trend of a multimodal approach with more conservative surgical options.

Case report

We present the case of a 6-year old patient diagnosed with a giant multicystic and rapidly recurrent craniopharyngioma, showing the current trends towards a multimodal therapeutic approach with less aggressive surgical options. We emphasize the use of two different intracystic cycles of a new formulation of pegylated 2a interferon. We make a review of the available literature focusing on historical and current treatment options.

Conclusion

Craniopharyngiomas remain a challenge due to the morbidity caused by both the disease and its treatment. The current trend towards a more conservative approach has many alternative treatment options, with intracystic pegyladed 2a interferon being a safe and effective choice, even in consecutive administrations.