Scholarlink

Purpose <p>The optimal management for neonatal intraventricular haemorrhage (IVH) remains uncertain. Neuroendoscopic lavage (NEL) has gained interest as a method for removal of intraventricular haematoma and debris, with outcomes suggesting it to be safe and efficacious for reducing the requirement for ventriculoperitoneal shunt (VPS) insertion. We present a large series assessing outcomes from NEL for neonatal IVH.</p> Methods <p>A retrospective review was carried out, between January 2011 and November 2023, identifying infants who underwent NEL following germinal matrix haemorrhage at our institution. Data was extracted on patient baseline demographics, comorbidities, complications, re-operation rate, and VPS requirement.</p> Results <p>Forty-four patients (28&#xa0;M:16F) underwent NEL at a median corrected age of 35<sup>+4</sup>&#xa0;weeks (range, 29<sup>+5</sup> to 51<sup>+1</sup>&#xa0;weeks). Post-procedure complications included 5 cerebrospinal fluid (CSF) leaks (11.4%), 2 infections (4.5%), and 1 rebleed within 72&#xa0;h of NEL (2.2%). All CSF leaks and infections were associated with a ventricular access device (VAD). The RR of post-operative infection with VAD versus without VAD insertion at the time of NEL was 23.8 (95% CI, 1.26–448.87; <i>p</i> = 0.035). NEL significantly reduced CSF red cell count (<i>p</i> = 0.013) and protein level (<i>p</i> = 0.017). Twenty-six out of forty-four patients (59.1%) required VPS insertion. The median time from NEL to VPS insertion was 52.8&#xa0;days (range 3 to 168&#xa0;days). On multivariate analysis, a significant baseline predictor of shunt independence was NEL at an earlier corrected age (<i>p</i> = 0.047).</p> Conclusions <p>NEL is a safe and potentially efficacious treatment for neonatal IVH. The procedure may reduce shunt dependence, particularly if performed earlier in the disease process.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Safety and efficacy of neuroendoscopic lavage for the management of neonatal intraventricular haemorrhage

  • 期刊论文

  • 发表日期：

    2025年9月1日

查看全文
  • Susan I. Honeyman,
  • Alexandros Boukas,
  • Sean C. Martin,
  • Tim Lawrence,
  • Amedeo Calisto,
  • Jayaratnam Jayamohan,
  • Shailendra Magdum

摘要

Purpose

The optimal management for neonatal intraventricular haemorrhage (IVH) remains uncertain. Neuroendoscopic lavage (NEL) has gained interest as a method for removal of intraventricular haematoma and debris, with outcomes suggesting it to be safe and efficacious for reducing the requirement for ventriculoperitoneal shunt (VPS) insertion. We present a large series assessing outcomes from NEL for neonatal IVH.

Methods

A retrospective review was carried out, between January 2011 and November 2023, identifying infants who underwent NEL following germinal matrix haemorrhage at our institution. Data was extracted on patient baseline demographics, comorbidities, complications, re-operation rate, and VPS requirement.

Results

Forty-four patients (28 M:16F) underwent NEL at a median corrected age of 35+4 weeks (range, 29+5 to 51+1 weeks). Post-procedure complications included 5 cerebrospinal fluid (CSF) leaks (11.4%), 2 infections (4.5%), and 1 rebleed within 72 h of NEL (2.2%). All CSF leaks and infections were associated with a ventricular access device (VAD). The RR of post-operative infection with VAD versus without VAD insertion at the time of NEL was 23.8 (95% CI, 1.26–448.87; p = 0.035). NEL significantly reduced CSF red cell count (p = 0.013) and protein level (p = 0.017). Twenty-six out of forty-four patients (59.1%) required VPS insertion. The median time from NEL to VPS insertion was 52.8 days (range 3 to 168 days). On multivariate analysis, a significant baseline predictor of shunt independence was NEL at an earlier corrected age (p = 0.047).

Conclusions

NEL is a safe and potentially efficacious treatment for neonatal IVH. The procedure may reduce shunt dependence, particularly if performed earlier in the disease process.