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Purpose <p>This study analyzes the prevalence of spinal deformities in patients who underwent in utero myelomeningocele (MMC) repair compared to those who had postnatal surgery.</p> Methods <p>Patients treated at Hospital São Paulo and Hospital e Maternidade Santa Joana between 2006 and 2021 were included. Selection was retrospective; external orthopedic system (EOS) imaging was performed prospectively. Only patients under 18 at the time of imaging were analyzed. Data collected included birth metrics, need for ventriculoperitoneal shunt, urinary/fecal incontinence, and postnatal complications. Radiographic analysis assessed scoliosis, pelvic parameters, and sagittal balance. Groups were compared using statistical tests (<i>p</i> &lt; 0.05).</p> Results <p>Seventy patients were evaluated: 47 had in utero repair and 23 postnatal. Groups were similar in age (<i>p</i> = 0.089) and gender (<i>p</i> = 0.725), but the in utero group had lower birth weight (<i>p</i> = 0.024) and gestational age (<i>p</i> = 0.004). Ventriculoperitoneal shunt requirement (<i>p</i> = 0.001), scoliosis incidence (<i>p</i> = 0.020), and urinary incontinence (<i>p</i> = 0.009) were significantly lower in the in utero group. Cobb angle did not differ significantly. Most postnatal complications were comparable, except for lower axial pelvic rotation in the in utero group (<i>p</i> = 0.024).</p> Conclusion <p>In utero MMC repair is associated with reduced rates of acquired scoliosis, need for shunting, and urinary incontinence, indicating a better overall prognosis compared to postnatal surgery.</p>

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Prevalence of spinal deformities in myelomeningoceles treated in utero and postnatally, utilizing 3D external orthopedic system (EOS) panoramic radiographic technology

  • 期刊论文

  • 发表日期：

    2025年8月25日

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  • Vinicius de Meldau Benites,
  • Vinicius Santos Baptista,
  • Matheus Galvão Valadares Bertolini Mussalem,
  • Marcos Devanir Silva da Costa,
  • Sergio Cavalheiro

摘要

Purpose

This study analyzes the prevalence of spinal deformities in patients who underwent in utero myelomeningocele (MMC) repair compared to those who had postnatal surgery.

Methods

Patients treated at Hospital São Paulo and Hospital e Maternidade Santa Joana between 2006 and 2021 were included. Selection was retrospective; external orthopedic system (EOS) imaging was performed prospectively. Only patients under 18 at the time of imaging were analyzed. Data collected included birth metrics, need for ventriculoperitoneal shunt, urinary/fecal incontinence, and postnatal complications. Radiographic analysis assessed scoliosis, pelvic parameters, and sagittal balance. Groups were compared using statistical tests (p < 0.05).

Results

Seventy patients were evaluated: 47 had in utero repair and 23 postnatal. Groups were similar in age (p = 0.089) and gender (p = 0.725), but the in utero group had lower birth weight (p = 0.024) and gestational age (p = 0.004). Ventriculoperitoneal shunt requirement (p = 0.001), scoliosis incidence (p = 0.020), and urinary incontinence (p = 0.009) were significantly lower in the in utero group. Cobb angle did not differ significantly. Most postnatal complications were comparable, except for lower axial pelvic rotation in the in utero group (p = 0.024).

Conclusion

In utero MMC repair is associated with reduced rates of acquired scoliosis, need for shunting, and urinary incontinence, indicating a better overall prognosis compared to postnatal surgery.