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<p>This study reports three cases of pediatric patients with polymorphous low-grade neuroepithelial tumor (PLNTY), confirmed by surgical pathology at our medical center, and presents their clinical and imaging features. PLNTY is a newly defined subtype in the 2021 WHO Classification of Tumors of the Central Nervous System (5th edition), categorized under pediatric-type diffuse low-grade glioma, WHO grade 1. The patients included one male and two females, aged 6, 9, and 9&#xa0;years, respectively. The tumors were located in the thalamus, temporal lobe, and frontal lobe. All cases showed calcifications on CT scans. Magnetic resonance imaging (MRI) revealed low signal on T1-weighted images (T1WI) and high signal on T2-weighted images (T2WI), with localized enhancement after contrast administration. Diffusion-weighted imaging (DWI) demonstrated high signal in two cases and low signal in one case. Positron emission tomography-computed tomography (PET-CT) showed increased metabolic activity in two cases, raising suspicion of high-grade malignant brain tumors preoperatively. Postoperatively, none of the patients experienced tumor recurrence during follow-up periods ranging from 1&#xa0;month to 6&#xa0;years. This study highlights the clinical and imaging characteristics of PLNTY in pediatric patients and underscores the diagnostic challenges as well as the generally favorable postoperative prognosis.</p>

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Imaging features of polymorphous low-grade neuroepithelial tumors of the young: a case series

  • 期刊论文

  • 发表日期：

    2025年7月1日

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  • Xinyao Wang,
  • Qiufeng Yin,
  • Shijie Liu,
  • Heng Zhao,
  • Haibo Zhang

摘要

This study reports three cases of pediatric patients with polymorphous low-grade neuroepithelial tumor (PLNTY), confirmed by surgical pathology at our medical center, and presents their clinical and imaging features. PLNTY is a newly defined subtype in the 2021 WHO Classification of Tumors of the Central Nervous System (5th edition), categorized under pediatric-type diffuse low-grade glioma, WHO grade 1. The patients included one male and two females, aged 6, 9, and 9 years, respectively. The tumors were located in the thalamus, temporal lobe, and frontal lobe. All cases showed calcifications on CT scans. Magnetic resonance imaging (MRI) revealed low signal on T1-weighted images (T1WI) and high signal on T2-weighted images (T2WI), with localized enhancement after contrast administration. Diffusion-weighted imaging (DWI) demonstrated high signal in two cases and low signal in one case. Positron emission tomography-computed tomography (PET-CT) showed increased metabolic activity in two cases, raising suspicion of high-grade malignant brain tumors preoperatively. Postoperatively, none of the patients experienced tumor recurrence during follow-up periods ranging from 1 month to 6 years. This study highlights the clinical and imaging characteristics of PLNTY in pediatric patients and underscores the diagnostic challenges as well as the generally favorable postoperative prognosis.