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<p>Aortic calcification detected on computed tomography (CT) is a marker of systemic atherosclerosis. Its clinical significance in predicting contrast-associated acute kidney injury (CA-AKI) after urgent coronary angiography remains unclear. A total of 140 patients (median age, 73 years [interquartile range 58–81]; female, 24.3%) were included. Calcification was assessed in the ascending aorta, aortic arch/descending aorta, abdominal aorta, coronary arteries, and renal arteries. The primary endpoint was CA-AKI, and the secondary endpoint was serial change in estimated glomerular filtration rate (eGFR) within 3 days after the procedure. CA-AKI occurred in 12.9% of patients. In univariate analysis, calcification of the aortic arch/descending aorta and abdominal aorta was associated with CA-AKI. Calcification of the ascending aorta was not associated with CA-AKI. After multivariable adjustment, calcification of the aortic arch/descending aorta remained associated with CA-AKI. Patients with calcification in these segments showed significantly attenuated improvement in eGFR over time. Among patients undergoing urgent coronary angiography, calcification of the aortic arch/descending aorta and abdominal aorta on CT was associated with CA-AKI and impaired short-term renal recovery. Aortic calcification may provide rapid preprocedural risk stratification.</p>

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Aortic calcification and contrast-associated acute kidney injury in patients undergoing urgent coronary angiography

  • 期刊论文

  • 发表日期：

    2026年7月25日

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  • Masatsugu Miyagawa,
  • Riku Arai,
  • Yoshikuni Shoji,
  • Ayame Saito,
  • Tatsuya Otake,
  • Yusuke Sasa,
  • Shonosuke Sugai,
  • Kazuki Iso,
  • Wataru Atsumi,
  • Eizo Tachibana,
  • Satoshi Kunimoto,
  • Keisuke Kojima,
  • Yasuo Okumura

摘要

Aortic calcification detected on computed tomography (CT) is a marker of systemic atherosclerosis. Its clinical significance in predicting contrast-associated acute kidney injury (CA-AKI) after urgent coronary angiography remains unclear. A total of 140 patients (median age, 73 years [interquartile range 58–81]; female, 24.3%) were included. Calcification was assessed in the ascending aorta, aortic arch/descending aorta, abdominal aorta, coronary arteries, and renal arteries. The primary endpoint was CA-AKI, and the secondary endpoint was serial change in estimated glomerular filtration rate (eGFR) within 3 days after the procedure. CA-AKI occurred in 12.9% of patients. In univariate analysis, calcification of the aortic arch/descending aorta and abdominal aorta was associated with CA-AKI. Calcification of the ascending aorta was not associated with CA-AKI. After multivariable adjustment, calcification of the aortic arch/descending aorta remained associated with CA-AKI. Patients with calcification in these segments showed significantly attenuated improvement in eGFR over time. Among patients undergoing urgent coronary angiography, calcification of the aortic arch/descending aorta and abdominal aorta on CT was associated with CA-AKI and impaired short-term renal recovery. Aortic calcification may provide rapid preprocedural risk stratification.