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Background <p>The Murray law-based quantitative flow ratio (µFR) is a promising angiography-derived physiology index that requires only one projection of coronary angiography. However, its clinical utility has not been fully evaluated and compared with quantitative flow ratio (QFR). To evaluate the clinical utility and diagnostic performance of µFR in assessing the functional significance of coronary artery stenosis and compare them with those of QFR. This retrospective, single-center, observational study included patients with chronic coronary syndrome who underwent wire-based fractional flow reserve (FFR) for de novo lesions with 30%–90% diameter stenosis by angiographic visual estimation. The diagnostic performances of µFR and QFR were evaluated based on the presence or absence of functionally significant stenosis (FFR ≤ 0.80). Receiver operating characteristic curve analysis was performed to compare the diagnostic performances of µFR and QFR. Among the 101 vessels from 79 patients, µFR was analyzable in all but 1 vessel, whereas QFR was unanalyzable in 19 vessels. µFR demonstrated better diagnostic accuracy and higher diagnostic performance than QFR. µFR had a higher analyzability rate with a shorter analysis time (88.3&#xa0;s vs. 263.6&#xa0;s, <i>p</i> &lt; 0.001) than QFR. µFR maintained a significant correlation with FFR, even in severely or moderately calcified lesions. µFR demonstrated superior analyzability, faster analysis, and better diagnostic performance than QFR in assessing the functional significance of coronary stenosis. µFR may be a better diagnostic index for assessing hemodynamically significant coronary stenosis than QFR.</p>

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Comparison of the clinical utility and diagnostic performance of Murray law–based quantitative flow ratio

  • 期刊论文

  • 发表日期：

    2026年1月21日

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  • Hiroshi Tsunamoto,
  • Yuto Osumi,
  • Takayoshi Toba,
  • Yoichiro Sugizaki,
  • Hiroyuki Kawamori,
  • Takashi Hiromasa,
  • Seigo Iwane,
  • Tetsuya Yamamoto,
  • Shota Naniwa,
  • Yuki Sakamoto,
  • Koshi Matsuhama,
  • Yuta Fukuishi,
  • Kotaro Higuchi,
  • Hiroya Okamoto,
  • Hiromasa Otake

摘要

Background

The Murray law-based quantitative flow ratio (µFR) is a promising angiography-derived physiology index that requires only one projection of coronary angiography. However, its clinical utility has not been fully evaluated and compared with quantitative flow ratio (QFR). To evaluate the clinical utility and diagnostic performance of µFR in assessing the functional significance of coronary artery stenosis and compare them with those of QFR. This retrospective, single-center, observational study included patients with chronic coronary syndrome who underwent wire-based fractional flow reserve (FFR) for de novo lesions with 30%–90% diameter stenosis by angiographic visual estimation. The diagnostic performances of µFR and QFR were evaluated based on the presence or absence of functionally significant stenosis (FFR ≤ 0.80). Receiver operating characteristic curve analysis was performed to compare the diagnostic performances of µFR and QFR. Among the 101 vessels from 79 patients, µFR was analyzable in all but 1 vessel, whereas QFR was unanalyzable in 19 vessels. µFR demonstrated better diagnostic accuracy and higher diagnostic performance than QFR. µFR had a higher analyzability rate with a shorter analysis time (88.3 s vs. 263.6 s, p < 0.001) than QFR. µFR maintained a significant correlation with FFR, even in severely or moderately calcified lesions. µFR demonstrated superior analyzability, faster analysis, and better diagnostic performance than QFR in assessing the functional significance of coronary stenosis. µFR may be a better diagnostic index for assessing hemodynamically significant coronary stenosis than QFR.