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Background <p>The incidence and progression of atrial fibrillation (AF), the most common type of cardiac arrhythmia, correlate with atrial fibrosis. An increased epicardial adipose tissue (EAT) volume is associated with increased atrial fibrosis. Although the presence and severity of atrial fibrosis have been evaluated through various invasive and noninvasive methods, reports examining the association between EAT volume (EATV) and the left atrial (LA) stiffness index through echocardiography or LA compliance as determined by LA pressure are lacking. Therefore, we investigated the relationship between EAT and the LA stiffness index and directly measured LA pressure in patients undergoing AF ablation.</p> Methods <p>We retrospectively examined 165 patients who underwent catheter ablation for AF between December 2022 and March 2025. The EATV was measured using contrast-enhanced computed tomography. The LA stiffness index was calculated as the ratio of the early mitral inflow velocity to the early annular tissue velocity. LA pulse pressure was assessed as the difference between peak and nadir LA pressure.</p> Results <p>A weak correlation was observed between the LA-EATV index (LA-EATVI) and the LA stiffness index. No significant correlation was observed between the LA-EATVI and LA pulse pressure.</p> Conclusions <p>Our study showed a weak correlation between the LA-EATVI and the LA stiffness index, but not with LA pulse pressure in patients with AF. Changes in the LA owing to EAT may need to be evaluated quantitatively and qualitatively.</p>

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Relationship between epicardial adipose tissue and left atrial stiffness estimated from echocardiographic parameters and left atrial pressure in patients with atrial fibrillation

  • 期刊论文

  • 发表日期：

    2025年11月23日

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  • Hikaru Hagiwara,
  • Kohei Ouchi,
  • Mana Suzuki,
  • Yumi Iwabuchi,
  • Takashi Okada,
  • Takuro Okamoto,
  • Jiro Koya,
  • Hirokazu Komoriyama,
  • Yoshiya Kato,
  • Toshihisa Anzai

摘要

Background

The incidence and progression of atrial fibrillation (AF), the most common type of cardiac arrhythmia, correlate with atrial fibrosis. An increased epicardial adipose tissue (EAT) volume is associated with increased atrial fibrosis. Although the presence and severity of atrial fibrosis have been evaluated through various invasive and noninvasive methods, reports examining the association between EAT volume (EATV) and the left atrial (LA) stiffness index through echocardiography or LA compliance as determined by LA pressure are lacking. Therefore, we investigated the relationship between EAT and the LA stiffness index and directly measured LA pressure in patients undergoing AF ablation.

Methods

We retrospectively examined 165 patients who underwent catheter ablation for AF between December 2022 and March 2025. The EATV was measured using contrast-enhanced computed tomography. The LA stiffness index was calculated as the ratio of the early mitral inflow velocity to the early annular tissue velocity. LA pulse pressure was assessed as the difference between peak and nadir LA pressure.

Results

A weak correlation was observed between the LA-EATV index (LA-EATVI) and the LA stiffness index. No significant correlation was observed between the LA-EATVI and LA pulse pressure.

Conclusions

Our study showed a weak correlation between the LA-EATVI and the LA stiffness index, but not with LA pulse pressure in patients with AF. Changes in the LA owing to EAT may need to be evaluated quantitatively and qualitatively.