<p>The COVID-19 epidemic has had a serious impact on the mental health of college students. This paper conducts relevant research on the effective management of college students’ mental health. This paper constructs an integrated student mental health management model based on artificial intelligence and multidimensional information intervention. By conducting all-round monitoring and intervention on students’ mental health, it realizes the comprehensive management and effective intervention of college students’ mental health. Starting from the impact of the COVID-19 epidemic on college students’ mental health, this paper introduces the application of artificial intelligence technology and multidimensional information technology in college students’ mental health management, and analyzes and predicts its implementation effect. This paper conducts a comparative test on the anxiety, depression, and life satisfaction of college students before and after multidimensional information technology intervention. The results show that the model can effectively alleviate college students’ anxiety, depression and other emotions and improve their life satisfaction. In terms of the accuracy of college students’ mental health intelligence assessment, the test results of this paper are as high as 92.9%. The experimental results show that the application of the artificial intelligence and multidimensional information intervention model designed in this paper in the integrated system of student mental health management has important prospects and potential.</p>