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Introduction <p>Calcium kidney stone disease, a common urinary tract disorder characterized by a high recurrence rate, remains poorly understood in terms of its recurrent etiology. Existing preventive measures are inadequate, limiting their clinical utility. Recent evidence suggests a significant role for epigenetic modifications in stone formation.</p> Methods <p>Based on expert-conducted PubMed literature searches, appropriate articles focusing on the investigation of epigenetic mechanisms in calcium kidney stone disease were carefully selected for inclusion in the study.</p> Results <p>The current understanding of calcium kidney stone disease indicates that epigenetic changes play a crucial role. Multiple studies have delved into the functions of DNA and mRNA methylation, histone and non-histone regulation, and non-coding RNA in the development of calcium kidney stones. Elucidating these molecular mechanisms holds promise for the development of more effective therapeutic and preventive strategies.</p> Conclusions <p>Calcium kidney stone disease poses a challenge in clinical management due to its high recurrence rate and the suboptimal efficacy of existing preventive interventions. Although recent research has shed light on the role of epigenetic modifications in stone formation, further in-depth investigation is imperative. Continued exploration of epigenetic mechanisms will be essential for the development of more effective therapeutic and preventive strategies to improve the outcomes for patients with calcium kidney stone disease.</p>

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Unravelling new mechanisms of occurrence and recurrence in calcium nephrolithiasis: the role of epigenetics

  • 期刊论文

  • 发表日期：

    2026年4月7日

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  • Hailan He,
  • Xiangan Lei,
  • Xiaofeng Zou,
  • Guoxi Zhang,
  • Xiaoning Wang,
  • Junrong Zou,
  • Zhilong Dong

摘要

Introduction

Calcium kidney stone disease, a common urinary tract disorder characterized by a high recurrence rate, remains poorly understood in terms of its recurrent etiology. Existing preventive measures are inadequate, limiting their clinical utility. Recent evidence suggests a significant role for epigenetic modifications in stone formation.

Methods

Based on expert-conducted PubMed literature searches, appropriate articles focusing on the investigation of epigenetic mechanisms in calcium kidney stone disease were carefully selected for inclusion in the study.

Results

The current understanding of calcium kidney stone disease indicates that epigenetic changes play a crucial role. Multiple studies have delved into the functions of DNA and mRNA methylation, histone and non-histone regulation, and non-coding RNA in the development of calcium kidney stones. Elucidating these molecular mechanisms holds promise for the development of more effective therapeutic and preventive strategies.

Conclusions

Calcium kidney stone disease poses a challenge in clinical management due to its high recurrence rate and the suboptimal efficacy of existing preventive interventions. Although recent research has shed light on the role of epigenetic modifications in stone formation, further in-depth investigation is imperative. Continued exploration of epigenetic mechanisms will be essential for the development of more effective therapeutic and preventive strategies to improve the outcomes for patients with calcium kidney stone disease.