Purpose <p>To evaluate the validity and reliability of the Arabic version of the Lower Urinary Tract Dysfunction Research Network Symptom Index-10 (LURN SI-10) questionnaire for assessing lower urinary tract symptoms (LUTs) in Arabic-speaking patients.</p> Methods <p>The LURN SI-10 was translated into Arabic following the Patient-Reported Outcome Consortium guidelines, with back-translation and a pilot study among 15 patients for clarity. The Arabic version of LURN-SI 10, and the validated Arabic versions of International Prostate Symptom Score (IPSS) and International Consultation on Incontinence Questionnaire Overactive Bladder (ICIQ-OAB) questionnaires were administered for patients with LUTs. Reliability, internal consistency and concurrent validity of LURN-SI 10 were established.</p> Results <p>From October 2024 to February 2025, 186 patients with LUTS were enrolled. The Arabic LURN SI-10 demonstrated high reliability (Cronbach’s alpha = 0.8; all subdomains &gt; 0.7). Significant positive correlations were found between LURN SI-10 with IPSS (<i>r</i> = 0.780, 0.833, 0.683, <i>p</i> &lt; 0.001) and ICIQ-OAB (<i>r</i> = 0.730, 0.768, 0.674 <i>p</i> &lt; 0.001) for all patients, males and females respectively. Frequency, urgency, nocturia, and weak stream domains of LURN SI-10 correlated significantly with their IPSS counterparts. Frequency, nocturia, urgency, and urge urinary incontinence (UUI) correlated with ICIQ-OAB domains. Significant positive correlations were noted between pain, urgency, and other domains, including post-void dribbling (PVD), bladder pain, and bother.</p> Conclusion <p>The Arabic LURN SI-10 is a valid and reliable tool for assessing LUTs, showing strong correlations with IPSS and ICIQ-OAB. The comprehensive assessment of PVD, UUI, stress urinary incontinence, and bladder pain enhances its utility over IPSS for both male and female patients with LUTS.</p>