Scholarlink

Purpose <p>We aimed to evaluate the impact of day- and night-time pad wetness on 2yrs-QoL after Radical Cystectomy (RC) with Orthotopic Neobladder (ON) from a Randomized Controlled Trial (RCT) aimed at comparing open RC (ORC) and Robot-Assisted RC (RARC) with intracorporeal (i) ON.</p> Methods <p>Between January 2018 and September 2020, 116 patients were enrolled. Data from self-assessed questionnaires (EORTC-QLQ-C30 and QLQ-BLM30) were collected. Unmodified HRQoL was defined as a 2yrs Global Health status/QoL increase ≥ 0 (ΔQL ≥ 0) from baseline. Quantitative analysis of continence status was evaluated through 3-day voiding diaries. We previously defined day-time continence as “complete dryness” (0gr pad wetness) and night-time continence as pad wetness ≤ 50gr.</p> Results <p>Out of 116 patients enrolled, 88 received ON, and 71 with a minimum 2yrs follow-up were included. Quantitative analysis of day- and night-time urinary continence are reported. Particularly, 44 patients (62%) were completely dry during the day, while 40 patients (57%) experienced night-time pad wetness ≤ 50gr. However, a day pad wetness &gt; 0gr significantly impact on 2yrs unmodified Global Health Status (<i>p</i> = 0.029), while only a night-time pad wetness ≥ 500gr significantly impacts on 2yrs unmodified Global Health Status (<i>p</i> = 0.005).</p> Conclusion <p>This study strengthens the need for a strict definition of day-time urinary continence after RC and ON, confirming complete dryness as a main driver of patients’ HRQoL. Conversely, nigh-time continence status seems to play a negligible role on subjectively assessed HRQoL.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Impact of pad wetness on health-related quality of life after radical cystectomy and orthotopic neobladder

  • 期刊论文

  • 发表日期：

    2025年9月10日

查看全文
  • Riccardo Mastroianni,
  • Andrea Iannuzzi,
  • Alberto Ragusa,
  • Gabriele Tuderti,
  • Umberto Anceschi,
  • Alfredo Maria Bove,
  • Aldo Brassetti,
  • Simone D’Annunzio,
  • Mariaconsiglia Ferriero,
  • Leonardo Misuraca,
  • Salvatore Guaglianone,
  • Rocco Papalia,
  • Giuseppe Simone

摘要

Purpose

We aimed to evaluate the impact of day- and night-time pad wetness on 2yrs-QoL after Radical Cystectomy (RC) with Orthotopic Neobladder (ON) from a Randomized Controlled Trial (RCT) aimed at comparing open RC (ORC) and Robot-Assisted RC (RARC) with intracorporeal (i) ON.

Methods

Between January 2018 and September 2020, 116 patients were enrolled. Data from self-assessed questionnaires (EORTC-QLQ-C30 and QLQ-BLM30) were collected. Unmodified HRQoL was defined as a 2yrs Global Health status/QoL increase ≥ 0 (ΔQL ≥ 0) from baseline. Quantitative analysis of continence status was evaluated through 3-day voiding diaries. We previously defined day-time continence as “complete dryness” (0gr pad wetness) and night-time continence as pad wetness ≤ 50gr.

Results

Out of 116 patients enrolled, 88 received ON, and 71 with a minimum 2yrs follow-up were included. Quantitative analysis of day- and night-time urinary continence are reported. Particularly, 44 patients (62%) were completely dry during the day, while 40 patients (57%) experienced night-time pad wetness ≤ 50gr. However, a day pad wetness > 0gr significantly impact on 2yrs unmodified Global Health Status (p = 0.029), while only a night-time pad wetness ≥ 500gr significantly impacts on 2yrs unmodified Global Health Status (p = 0.005).

Conclusion

This study strengthens the need for a strict definition of day-time urinary continence after RC and ON, confirming complete dryness as a main driver of patients’ HRQoL. Conversely, nigh-time continence status seems to play a negligible role on subjectively assessed HRQoL.