Purpose <p>To assess the efficacy of star-like internal urethrotomy on vesicourethral anastomotic stenosis (VUAS) and its impact on voiding and continence outcomes.</p> Methods <p>This observational study was conducted in two tertiary referral hospitals. 31 patients confirmed with VUAS after radical prostatectomy or cystectomy were included. A novel Star-like Incision Urethrotomy procedure focused on a shallow incision on scar tissue all around the anastomotic site was performed. The primary outcome was the procedure’s impact on urinary voiding and continence, assessed using the International Prostate Symptom Score (IPSS) and the International Consultation on Incontinence Questionnaire Short Form (ICIQ-SF).</p> Results <p>Participants had a mean age of 68.32 years, 27 (87%) with a history of radical prostatectomy and 4 (13%) with a history of radical cystectomy, who presented to our clinic with urinary obstructive symptoms. We performed Star-like incision on the anastomotic site using a ureteral catheter as a guide. During patient follow-up, significant improvements were observed in urinary flow and continence. At one month postoperatively, the mean IPSS score decreased from 26.58 to 13.39, and the ICIQ-SF score initially increased from 4.48 to 6.87 at first and then reduced to about 4. These improvements were sustained throughout the six regular follow-ups, with an IPSS score of 12.8 and an ICIQ-SF score of 3.6. Besides these improvements, 5 (16%) patients required repeated urethrotomy due to recurrence of stenosis.</p> Conclusion <p>Endoscopic treatment with Star-like incision for VUAS has promising outcomes compared to other endoscopic treatments.</p>