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Introduction <p>MRI-targeted biopsies enhance prostate cancer (PCa) diagnostics, but systematic distant biopsies increase overdiagnosis and overtreatment. Regional biopsies may optimize diagnostic efficiency.</p> Methods <p>This prospective single-center study included biopsy-naïve patients undergoing transperineal MRI-guided biopsies with cognitive fusion and regional sampling.</p> Results <p>Among 50 patients, 66% had clinically significant PCa, 16% insignificant PCa, and 18% no cancer. No re-biopsies were needed for non-cancerous cases. Of 12 patients undergoing nerve-sparing radical prostatectomy, 25% had a bilateral disease, with two positive margins.</p> Conclusion <p>This novel biopsy template may help reduce unnecessary sampling and associated risks. Larger comparative studies are needed to confirm these findings.</p>

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Targeted and regional biopsy in prostate cancer: first real-world data

  • 期刊论文

  • 发表日期：

    2025年3月26日

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  • Thibaut Long-Depaquit,
  • Renaud Corral,
  • Alessandro Uleri,
  • Arthur Peyrottes,
  • Jennifer Campagna,
  • Harry Toledano,
  • Cyrille Bastide,
  • Michael Baboudjian

摘要

Introduction

MRI-targeted biopsies enhance prostate cancer (PCa) diagnostics, but systematic distant biopsies increase overdiagnosis and overtreatment. Regional biopsies may optimize diagnostic efficiency.

Methods

This prospective single-center study included biopsy-naïve patients undergoing transperineal MRI-guided biopsies with cognitive fusion and regional sampling.

Results

Among 50 patients, 66% had clinically significant PCa, 16% insignificant PCa, and 18% no cancer. No re-biopsies were needed for non-cancerous cases. Of 12 patients undergoing nerve-sparing radical prostatectomy, 25% had a bilateral disease, with two positive margins.

Conclusion

This novel biopsy template may help reduce unnecessary sampling and associated risks. Larger comparative studies are needed to confirm these findings.