Scholarlink

Purpose <p>To evaluate MRI and histological concordance in prostate cancer (PCa) identification via mapped transperineal biopsies.</p> Methodology <p>Retrospective per-lesion analysis of patients undergoing MRI and transperineal biopsy at the Valencian Institute of Oncology (2016–2024) using CAPROSIVO PCa data. Patients underwent MRI, with or without regions of interest (ROI), followed by transperineal biopsies (3–5 cores/ROI, 20–30 systematic). Sensitivity (Se), specificity (Sp), negative predictive value (NPV), positive predictive value (PPV), and area under the curve (AUC) were calculated, considering PI-RADS 3 lesions as positive or negative. Gleason Grade Group (GG) &gt; 1 defined clinically significant PCa (csPCa).</p> Results <p>1817 lesions were analyzed from 1325 patients (median age 67, median PSA 6.3 ng/ml). 53% MRI were negative, GG &gt; 1 prevalence was 29.1%. MRI-negative cases showed varying PCa rates: 57.4% negative, 34.3% GG 1, and 8.3% GG &gt; 1. PI-RADS 3 lesions had mixed outcomes: 45.6% benign, 29.5% GG 1, and 24.9% GG &gt; 1. 9.2% PI-RADS 4–5 lesions were negative, 23% GG 1, and 67.8% GG &gt; 1. For PI-RADS 3 lesions considered positive, Se, Sp, NPV, PPV, and AUC were 84.9%, 68.4%, 91.7%, 52.6%, and 0.77 respectively. Considering PI-RADS 3 as negative yielded 70.6% Se, 86.2%, Sp, 87.7% NPV, 67.8% PPV, and 0.78 AUC.</p> Conclusion <p>MRI and mapped prostate biopsies exhibited moderate concordance. MRI could miss up to one in ten csPCafoci and misinterpret one in two ROIs. Careful MRI interpretation is crucial for optimizing patient care.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Correction: Can we rely on magnetic resonance imaging for prostate cancer detection and surgical planning? Comprehensive analysis of a large cohort of patients undergoing transperineal mapped biopsies

  • 期刊论文

  • 发表日期：

    2025年3月12日

查看全文
  • Nidia Gómez Diez,
  • Pedro de Pablos-Rodríguez,
  • David Sánchez-Mateos Manzaneque,
  • María Isabel Martín García,
  • Paula Pelechano Gómez,
  • María Barrios Benito,
  • Ana Calatrava Fons,
  • Jessica Aliaga Patiño,
  • Juan Boronat Catalá,
  • Álvaro Gómez-Ferrer Lozano,
  • Augusto Wong Gutiérrez,
  • Ángel García Cortés,
  • Miguel Ramírez Backhaus,
  • Juan Casanova Ramón Borja,
  • Manel Beamud Cortés,
  • José Luis Domínguez Escrig,
  • Antonio Coy García

摘要

Purpose

To evaluate MRI and histological concordance in prostate cancer (PCa) identification via mapped transperineal biopsies.

Methodology

Retrospective per-lesion analysis of patients undergoing MRI and transperineal biopsy at the Valencian Institute of Oncology (2016–2024) using CAPROSIVO PCa data. Patients underwent MRI, with or without regions of interest (ROI), followed by transperineal biopsies (3–5 cores/ROI, 20–30 systematic). Sensitivity (Se), specificity (Sp), negative predictive value (NPV), positive predictive value (PPV), and area under the curve (AUC) were calculated, considering PI-RADS 3 lesions as positive or negative. Gleason Grade Group (GG) > 1 defined clinically significant PCa (csPCa).

Results

1817 lesions were analyzed from 1325 patients (median age 67, median PSA 6.3 ng/ml). 53% MRI were negative, GG > 1 prevalence was 29.1%. MRI-negative cases showed varying PCa rates: 57.4% negative, 34.3% GG 1, and 8.3% GG > 1. PI-RADS 3 lesions had mixed outcomes: 45.6% benign, 29.5% GG 1, and 24.9% GG > 1. 9.2% PI-RADS 4–5 lesions were negative, 23% GG 1, and 67.8% GG > 1. For PI-RADS 3 lesions considered positive, Se, Sp, NPV, PPV, and AUC were 84.9%, 68.4%, 91.7%, 52.6%, and 0.77 respectively. Considering PI-RADS 3 as negative yielded 70.6% Se, 86.2%, Sp, 87.7% NPV, 67.8% PPV, and 0.78 AUC.

Conclusion

MRI and mapped prostate biopsies exhibited moderate concordance. MRI could miss up to one in ten csPCafoci and misinterpret one in two ROIs. Careful MRI interpretation is crucial for optimizing patient care.