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<p>Bacterial skin infections are an increasing global health burden. Floridosides (floridoside and isofloridoside) are neutral glycosides widely found in red algae. In this study, floridosides were isolated from <i>Pyropia haitanensis</i>. Chemical analysis indicated that the molar ratio of floridoside to isofloridoside was 1:7.13. We investigated the antimicrobial efficacy of floridosides against <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i>, two common cutaneous pathogens. Growth kinetics revealed that floridosides inhibited the proliferation of <i>S. aureus</i> and <i>P. aeruginosa</i> in a concentration-independent manner. Confocal microscopy and plate counting demonstrated a reduced viable count of bacteria by floridosides at sub-inhibitory concentration (0.006 25 mg/mL). Scanning electron microscopy (SEM) and protein leakage assays confirmed intact membrane integrity. Floridosides may act as an analog of bacterial quorum sensing (QS) signal molecules to regulate bacterial activity. Molecular docking results demonstrating moderate binding energy suggest its potential to bind to QS receptors and subsequently influence metabolic processes. Floridosides exhibited no cytotoxicity toward HaCaT cells (viability&gt;99.5%) and low hemolysis rate of 3.2% at 1 mg/mL. This study demonstrates that floridosides exhibited significant activity in modulating the skin microbiome.</p>

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Floridosides from Pyropia haitanensis: antimicrobial potential against cutaneous pathogens

  • 期刊论文

  • 发表日期：

    2026年6月2日

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  • Jinghang Xu,
  • Quanbin Zhang,
  • Jing Wang,
  • Lihua Geng,
  • Yang Yue,
  • Ning Wu

摘要

Bacterial skin infections are an increasing global health burden. Floridosides (floridoside and isofloridoside) are neutral glycosides widely found in red algae. In this study, floridosides were isolated from Pyropia haitanensis. Chemical analysis indicated that the molar ratio of floridoside to isofloridoside was 1:7.13. We investigated the antimicrobial efficacy of floridosides against Staphylococcus aureus and Pseudomonas aeruginosa, two common cutaneous pathogens. Growth kinetics revealed that floridosides inhibited the proliferation of S. aureus and P. aeruginosa in a concentration-independent manner. Confocal microscopy and plate counting demonstrated a reduced viable count of bacteria by floridosides at sub-inhibitory concentration (0.006 25 mg/mL). Scanning electron microscopy (SEM) and protein leakage assays confirmed intact membrane integrity. Floridosides may act as an analog of bacterial quorum sensing (QS) signal molecules to regulate bacterial activity. Molecular docking results demonstrating moderate binding energy suggest its potential to bind to QS receptors and subsequently influence metabolic processes. Floridosides exhibited no cytotoxicity toward HaCaT cells (viability>99.5%) and low hemolysis rate of 3.2% at 1 mg/mL. This study demonstrates that floridosides exhibited significant activity in modulating the skin microbiome.