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<p>Gut microbiota can modulate nutrient metabolism, considerably affecting host growth and development. However, mechanisms by which gut microbiota regulate large yellow croaker (LYC; <i>Larimichthys crocea</i>) growth remain unclear. We assessed gut contents of fast-growing male (IWHM) and female (IWHF) LYCs, and slow-growing male (IWLM) and female (IWLF) LYCs; and the macrogenomics and metabolomics of the data were analyzed. Gut microbiota composition significantly differed among LYCs with different growth rates: <i>Vibrio</i> abundance was considerably lower in IWHM LYCs (2.53%) than in IWLM LYCs (41.47%); Arthrobacter D abundance was the highest in IWHF LYCs (8.19%) but the lowest in IWLF LYCs (1.52%). Moreover, 124 and 483 differential metabolites were noted in IWHM-IWLM and IWHF-IWLF LYC pairs, respectively. Phylum Firmicutes can enhance the nutritional metabolism in LYCs. Most <i>Vibrio</i> species may disrupt intestinal homeostasis and compromise the immune function of LYCs. Chorismic acid, phenylethyl glucosinolate, Phe-Ala, Asp-Pro, raffinose, and linolenic acid are likely to serve as key metabolites involved in the growth and metabolic processes of LYCs. Finally, we established a model for gut microbiota-metabolite relationship in LYCs to understand molecular mechanisms by which gut microbiota regulates nutrient metabolism. This study revealed the differences in gut microbiota between LYCs with high and low growth rates and provided unique insights into the regulation of LYC growth by the gut microbiota.</p>

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Potential molecular mechanism of growth difference in large yellow croaker: metabolomic and metagenomic analyses

  • 期刊论文

  • 发表日期：

    2025年10月25日

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  • Hao Huang,
  • Zhenheng Cheng,
  • Guangde Qiao,
  • Yabing Wang,
  • Quanxin Gao,
  • Shiming Peng

摘要

Gut microbiota can modulate nutrient metabolism, considerably affecting host growth and development. However, mechanisms by which gut microbiota regulate large yellow croaker (LYC; Larimichthys crocea) growth remain unclear. We assessed gut contents of fast-growing male (IWHM) and female (IWHF) LYCs, and slow-growing male (IWLM) and female (IWLF) LYCs; and the macrogenomics and metabolomics of the data were analyzed. Gut microbiota composition significantly differed among LYCs with different growth rates: Vibrio abundance was considerably lower in IWHM LYCs (2.53%) than in IWLM LYCs (41.47%); Arthrobacter D abundance was the highest in IWHF LYCs (8.19%) but the lowest in IWLF LYCs (1.52%). Moreover, 124 and 483 differential metabolites were noted in IWHM-IWLM and IWHF-IWLF LYC pairs, respectively. Phylum Firmicutes can enhance the nutritional metabolism in LYCs. Most Vibrio species may disrupt intestinal homeostasis and compromise the immune function of LYCs. Chorismic acid, phenylethyl glucosinolate, Phe-Ala, Asp-Pro, raffinose, and linolenic acid are likely to serve as key metabolites involved in the growth and metabolic processes of LYCs. Finally, we established a model for gut microbiota-metabolite relationship in LYCs to understand molecular mechanisms by which gut microbiota regulates nutrient metabolism. This study revealed the differences in gut microbiota between LYCs with high and low growth rates and provided unique insights into the regulation of LYC growth by the gut microbiota.