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<p>Efficient peptide adsorption on metasurfaces is essential for advanced biosensing applications. In this study, we demonstrate how ellipsometric measurements coupled with numerical simulations allow for real-time tracking of temporin-SHa peptide adsorption on gold metasurfaces. By characterizing spectral shifts at 660 nm, 920 nm, and 1000 nm, we reveal a rapid saturation of surface coverage after 3.5&#xa0;h, with a significant preferential adsorption at the resonator ends. Our approach provides a novel methodology for monitoring peptide binding, which could be applied to a wide range of biosensor designs.</p>

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Probing peptide adsorption kinetics and regioselectivity via multipolar plasmonic modes of gold resonators

  • 期刊论文

  • 发表日期：

    2025年7月21日

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  • Mathieu Nicolas,
  • Shuhui Yang,
  • Christophe Méthivier,
  • Souhir Boujday,
  • Bruno Gallas

摘要

Efficient peptide adsorption on metasurfaces is essential for advanced biosensing applications. In this study, we demonstrate how ellipsometric measurements coupled with numerical simulations allow for real-time tracking of temporin-SHa peptide adsorption on gold metasurfaces. By characterizing spectral shifts at 660 nm, 920 nm, and 1000 nm, we reveal a rapid saturation of surface coverage after 3.5 h, with a significant preferential adsorption at the resonator ends. Our approach provides a novel methodology for monitoring peptide binding, which could be applied to a wide range of biosensor designs.