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<p>A theoretical and simulation based plasmonic sensor is proposed for the detection of colorectal cancer in the near infrared (NIR) region. Plasmonic metal made of silver (Ag) is considered at the top of a calcium fluoride (CaF2) prism. The top layer is bovine serum albumin (BSA) which will act as linker for colorectal tissues. The goal of the simulation is to maximize radiative damping and attain optimum radiation damping (ORD) conditions using Ag–KTaO<sub>3</sub>–BSA heterojunction to obtain highest possible figure of merit (FOM). The optimization process involves the variation of Ag and KTaO<sub>3</sub> layer thicknesses (i.e. d<sub>M</sub> and d<sub>A</sub> respectively) as well as the operating wavelength (λ) in the NIR (nearby 1000&#xa0;nm) using 2D simulation approach. After concurrent variation of thicknesses, a high value of FOM about 6551 RIU<sup>− 1</sup> at d<sub>1</sub> = 47.7&#xa0;nm, d<sub>2</sub> = 2.4&#xa0;nm and λ = 1006.8&#xa0;nm has been obtained. This can be treated as a condition of ORD. Power loss ratio (PLR), electric field enhancement factor (FEF) and Rayleigh scattering factor (RSF) are calculated to be 3.134, 1.0792 and 0.97&#xa0;μm<sup>− 4</sup> respectively. Overall sensor performance, examined by combined performance factor (CPF) for the proposed sensor is 22684.02 µm<sup>4</sup>/RIU.</p> Graphical Abstract <p></p>

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Optimization of a plasmonic biosensor using BSA layer for colorectal cancer detection under optimum radiation damping

  • 期刊论文

  • 发表日期：

    2025年5月10日

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  • Sudhir Shukla,
  • D. K. Dwivedi,
  • Pooja Lohia

摘要

A theoretical and simulation based plasmonic sensor is proposed for the detection of colorectal cancer in the near infrared (NIR) region. Plasmonic metal made of silver (Ag) is considered at the top of a calcium fluoride (CaF2) prism. The top layer is bovine serum albumin (BSA) which will act as linker for colorectal tissues. The goal of the simulation is to maximize radiative damping and attain optimum radiation damping (ORD) conditions using Ag–KTaO3–BSA heterojunction to obtain highest possible figure of merit (FOM). The optimization process involves the variation of Ag and KTaO3 layer thicknesses (i.e. dM and dA respectively) as well as the operating wavelength (λ) in the NIR (nearby 1000 nm) using 2D simulation approach. After concurrent variation of thicknesses, a high value of FOM about 6551 RIU− 1 at d1 = 47.7 nm, d2 = 2.4 nm and λ = 1006.8 nm has been obtained. This can be treated as a condition of ORD. Power loss ratio (PLR), electric field enhancement factor (FEF) and Rayleigh scattering factor (RSF) are calculated to be 3.134, 1.0792 and 0.97 μm− 4 respectively. Overall sensor performance, examined by combined performance factor (CPF) for the proposed sensor is 22684.02 µm4/RIU.

Graphical Abstract