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<p>Strontium-enriched mesoporous bioactive glass nanoparticles (Sr-MBGNPs) were synthesized through a sol–gel process employing oxalic acid as a catalyst to facilitate hydrolysis and improved nanoparticles formation. The study was undertaken to develop bioactive nanoparticles with enhanced functionality for bone tissue engineering applications. Structural characterization by X-ray diffraction (XRD) confirmed the amorphous nature of the synthesized material, while high-resolution scanning electron microscopy (HR-SEM) revealed the formation of spherical nanoparticles with an average size of 500&#xa0;nm. The <i>in vitro</i> bioactivity of Sr-MBGNPs was demonstrated by the formation of a hydroxyapatite layer following immersion in simulated body fluid (SBF). Ion release analysis using inductively coupled plasma optical emission spectroscopy (ICP-OES) showed the sustained release of Sr, Ca, Si, and P ions, respectively. Cytocompatibility assessment indicated a cell viability of 100% at a concentration of 3.12&#xa0;µg mL⁻¹, confirming the material’s biocompatible nature. The nanoparticles exhibited antibacterial activity against <i>Staphylococcus aureus</i>with inhibition zone of 9&#xa0;mm. Furthermore, drug-release studies demonstrated a sustained release pattern, achieving 83 % at pH 7.4 over 24&#xa0;h/day. The incorporation of strontium into the mesoporous bioglass matrix improved bioactivity, ion-release characteristics, antibacterial performance, and biological response, highlighting the potential of Sr-MBGNPs as a multifunctional biomaterial for bone regeneration and localized therapeutic delivery.</p>

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Oxalic acid-directed synthesis of strontium-doped mesoporous bioactive glass nanoparticles with enhanced bone regenerative ability

  • 期刊论文

  • 发表日期：

    2026年7月29日

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  • A. Shalini,
  • K. Deepa,
  • P. Paulraj,
  • K. Margandan,
  • S. Meenakshi,
  • Subash C. B. Gopinath

摘要

Strontium-enriched mesoporous bioactive glass nanoparticles (Sr-MBGNPs) were synthesized through a sol–gel process employing oxalic acid as a catalyst to facilitate hydrolysis and improved nanoparticles formation. The study was undertaken to develop bioactive nanoparticles with enhanced functionality for bone tissue engineering applications. Structural characterization by X-ray diffraction (XRD) confirmed the amorphous nature of the synthesized material, while high-resolution scanning electron microscopy (HR-SEM) revealed the formation of spherical nanoparticles with an average size of 500 nm. The in vitro bioactivity of Sr-MBGNPs was demonstrated by the formation of a hydroxyapatite layer following immersion in simulated body fluid (SBF). Ion release analysis using inductively coupled plasma optical emission spectroscopy (ICP-OES) showed the sustained release of Sr, Ca, Si, and P ions, respectively. Cytocompatibility assessment indicated a cell viability of 100% at a concentration of 3.12 µg mL⁻¹, confirming the material’s biocompatible nature. The nanoparticles exhibited antibacterial activity against Staphylococcus aureuswith inhibition zone of 9 mm. Furthermore, drug-release studies demonstrated a sustained release pattern, achieving 83 % at pH 7.4 over 24 h/day. The incorporation of strontium into the mesoporous bioglass matrix improved bioactivity, ion-release characteristics, antibacterial performance, and biological response, highlighting the potential of Sr-MBGNPs as a multifunctional biomaterial for bone regeneration and localized therapeutic delivery.