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<p>A novel biologically active vanadium(V) complex, (GH)₄[(VO₂)₄(Phth)₄]·2&#xa0;H₂O, was synthesized from vanadyl sulfate pentahydrate, aminoguanidine bicarbonate, and phthalic acid. The complex was characterized by elemental analysis, spectroscopic methods, thermogravimetric analysis, and single-crystal X-ray diffraction. Structural analysis revealed a distorted V₄O₈ cubane-type core surrounded by four guanylhydrazinium/phthalato units. The vanadium(V) center adopts a distorted octahedral geometry, and the complex crystallizes in the triclinic system with space group P–1. Hirshfeld surface analysis, supported by 2D fingerprint plots and 3D surfaces, was employed to examine intermolecular interactions and hydrogen-bonding patterns in the crystal lattice. The major intermolecular contacts were O···H/H···O (38.1%), followed by H···H (34.3%) and C···H/H···C (2.3%), indicating that hydrogen bonding and weak intermolecular interactions significantly contribute to crystal stabilization. The biological activity of the complex was evaluated in vitro against Aspergillus niger, Pseudomonas aeruginosa, and Escherichia coli. The results indicate significant antimicrobial and antifungal activity, highlighting the potential of the vanadium(V) complex as a biologically active metal-based therapeutic agent.</p> Graphical Abstract <p></p>

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A novel oxo-bridged tetranuclear guanylhydrazinium vanadium(V) phthalate dihydrate complex: synthesis, structural characterization, hirshfeld surface analysis, and biological activity

  • 期刊论文

  • 发表日期：

    2026年7月29日

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  • K. Naresh,
  • A. Mani,
  • B. Archana,
  • V. Azeezaa,
  • S. Jayasree,
  • B. N. Sivasankar,
  • B. Preethi,
  • C. Sivakumar

摘要

A novel biologically active vanadium(V) complex, (GH)₄[(VO₂)₄(Phth)₄]·2 H₂O, was synthesized from vanadyl sulfate pentahydrate, aminoguanidine bicarbonate, and phthalic acid. The complex was characterized by elemental analysis, spectroscopic methods, thermogravimetric analysis, and single-crystal X-ray diffraction. Structural analysis revealed a distorted V₄O₈ cubane-type core surrounded by four guanylhydrazinium/phthalato units. The vanadium(V) center adopts a distorted octahedral geometry, and the complex crystallizes in the triclinic system with space group P–1. Hirshfeld surface analysis, supported by 2D fingerprint plots and 3D surfaces, was employed to examine intermolecular interactions and hydrogen-bonding patterns in the crystal lattice. The major intermolecular contacts were O···H/H···O (38.1%), followed by H···H (34.3%) and C···H/H···C (2.3%), indicating that hydrogen bonding and weak intermolecular interactions significantly contribute to crystal stabilization. The biological activity of the complex was evaluated in vitro against Aspergillus niger, Pseudomonas aeruginosa, and Escherichia coli. The results indicate significant antimicrobial and antifungal activity, highlighting the potential of the vanadium(V) complex as a biologically active metal-based therapeutic agent.

Graphical Abstract